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Clinical Trials in Japan / NCT06945510
Starting soon Not applicable

PCT Guided Antibiotics Use in Critically Ill Adult Patients in China

NCT06945510 · tracked via the Priya Life Science Japan tracker
Sponsor
China-Japan Friendship Hospital
Phase
Not applicable
Started
2025-06-30
Last updated
2025-04-25

Condition(s) studied

Sepsis

Investigational drug(s) / intervention(s)

PCT detection

PCT detection: Clinicians will prescribe PCT tests every day for enrolled patients, with assigning a dedicated person monitoring the daily PCT results. Once the PCT \<0.5 ng/ml or ΔPCT (drop from the peak value) \>80%, the clinicians will receive a notification and will strictly adhere to guidelines and PCT values to adjust antibiotic prescriptions.

Study summary

Procalcitonin (PCT) has been widely used in the diagnosis and treatment of bacterial infectious diseases in China. The investigators aim to establish an algorithm based on BRAHMS PCT (VIDAS PCT) for patients with severe infections or sepsis in the EICU to reduce antibiotic exposure and verify its validity in the reduction of antibiotic exposure, clinical outcomes and costs saving.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age≥18 * Suspected or confirmed bacterial patients * Stay EICU more than 3 days Exclusion Criteria: * age under 18 years; * PCT concentration throughout the entire hospitalization less than 0.5 ng/ml ; * known pregnancy; expected stay in the EICU less than 3 days; * bone-marrow transplant or chemotherapy-induced neutropenia (\<500 neutrophils per mL); * infections for which long-term antibiotic treatment is strongly recommended (ie, infective endocarditis, osteoarticular infections, anterior mediastinitis after cardiac surgery, hepatic or cerebral abscesses, chronic prostatitis, or infection with Mycobacterium tuberculosis, Pneumocystis jirovecii, or Toxoplasma gondii); * poor chance of survival, defined as a simplified acute physiology score (SAPS II) of more than 65 points at screening; and do-not-resuscitate orders

Primary outcome measure(s)

  • Total duration of antibiotics use — From the day the patient was admitted to the EICU until the patient left the EICU, calculate how many days were antibiotics used.

Trial sites (1)

FacilityCityRegionStatus
China-Japan Friendship Hospital Beijing China

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06945510 on ClinicalTrials.gov ↗ ← All trials in Japan