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Clinical Trials in Japan / NCT06251687
Recruiting Not applicable

Application of Transbronchial Cryobiopsy in the Diagnosis of Progressive Pulmonary Fibrosis

NCT06251687 · tracked via the Priya Life Science Japan tracker
Sponsor
China-Japan Friendship Hospital
Phase
Not applicable
Started
2024-02-01
Last updated
2025-02-10

Condition(s) studied

Pulmonary FibrosisTransbronchial Cryobiopsy

Investigational drug(s) / intervention(s)

Transbronchial Cryobiopsy，TBLCTransbronchial Lung Biopsy，TBLB

Transbronchial Cryobiopsy，TBLC: Transbronchial lung cryobiopsy (TBLC) is a novel technique that has proved its diagnostic value in various diffuse parenchymal lung diseases

Transbronchial Lung Biopsy，TBLB: Transbronchial lung biopsy (TBLB) is a relatively safe technique routinely employed by pulmonologists for the diagnosis of diffuse parenchymal lung disease

Study summary

The goal of this clinical study is to learn about the diagnostic effectiveness, safety, and influencing factors of transbronchial cryobiopsy（TBLC）in progressive pulmonary fibrosis. The main question it aims to answer are: • Determine the prognosis, health economics, and therapeutic strategy changes of patients with TBLC retrograde malleable pulmonary fibrosis. Participants will be randomly divided into two groups, and received TBLB or TBLC.

Eligibility

Sex
ALL
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria: Patients with PPF, ≥18 years of age, unclassified ILD, HRCT ≤3 months, forced vital capacity (FVC)≥50% predicted value, pulmonary carbon monoxide diffusion (DLCO)≥35% predicted value, echocardiography ≤12 months, estimated pulmonary systolic blood pressure ≤40 mmHg, Body mass index (BMI)≤35 kg/m2. Exclusion Criteria: Patients with platelet counts below 50,000×109/L or International Normalized ratio of prothrombin time (INR) above 1.5 are not eligible for TBLC

Primary outcome measure(s)

  • the diagnostic performance of transbronchial cryobiopsy（TBLC） — 1 month after transbronchial cryobiopsy
    the sensitivity and specificity of transbronchial cryobiopsy（TBLC）in suspected progressive pulmonary fibrosis

Trial sites (1)

FacilityCityRegionStatus
China-Japan Friendship Hospital Beijing Beijing Municipality Recruiting

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Other trials for the same condition

Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis Starting soon
Antifibrotic Therapy Decision-Making in Pulmonary Fibrosis Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06251687 on ClinicalTrials.gov ↗ ← All trials in Japan