A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment
Condition(s) studied
Investigational drug(s) / intervention(s)
Talquetamab: Talquetamab will be administered subcutaneously.
Daratumumab: Daratumumab will be administered subcutaneously.
Pomalidomide: Pomalidomide will be administered orally.
Dexamethasone: Dexamethasone will be administered orally or intravenously.
Study summary
The purpose of the study is to compare the efficacy of talquetamab subcutaneous(ly) (SC) in combination with daratumumab SC and pomalidomide (Tal-DP) and talquetamab SC in combination with daratumumab SC (Tal-D), respectively, with daratumumab SC in combination with pomalidomide and dexamethasone (DPd).
Eligibility
Primary outcome measure(s)
- Progression-Free Survival (PFS) — Up to 6 years 6 months
PFS is defined as time from the date of randomization to the first documentation of disease progression, or death due to any cause, whichever is reported first.
Trial sites (216)
| Facility | City | Region | Status |
|---|---|---|---|
| The University of Arizona Cancer Center | Tucson | Arizona | |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | |
| Norwalk Hospital-oncology | Norwalk | Connecticut | |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | |
| George Washington University | Washington D.C. | District of Columbia | |
| Memorial Healthcare System | Hollywood | Florida | |
| University of Miami Health System | Miami | Florida | |
| University Of Illinois | Chicago | Illinois | |
| University of Kansas | Westwood | Kansas | |
| Tulane University Hospital & Clinics | New Orleans | Louisiana | |
| Ochsner Health System | New Orleans | Louisiana | |
| Johns Hopkins University | Baltimore | Maryland | |
| Massachusetts General | Boston | Massachusetts | |
| Boston University Medical Center | Boston | Massachusetts | |
| University of Massachusetts Medical School | Worcester | Massachusetts | |
| University of Michigan Health System | Ann Arbor | Michigan | |
| University Of Minnesota | Minneapolis | Minnesota | |
| University of Mississippi Medical Center | Jackson | Mississippi | |
| Washington University School Of Medicine | St Louis | Missouri | |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | |
| NYU Langone Health | New York | New York | |
| SUNY Upstate Medical University | Syracuse | New York | |
| University of North Carolina | Chapel Hill | North Carolina | |
| Levine Cancer Institute, Carolinas HealthCare System | Charlotte | North Carolina | |
| Novant Health 1 | Charlotte | North Carolina | |
| Novant Health | Winston-Salem | North Carolina | |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | |
| The Ohio State University Wexner Medical Center - James Cancer Hospital | Columbus | Ohio | |
| OhioHealth | Columbus | Ohio | |
| Thomas Jefferson University | Philadelphia | Pennsylvania | |
| Medical University of South Carolina | Charleston | South Carolina | |
| Baptist Cancer Center | Memphis | Tennessee | |
| Houston Methodist Hospital | Houston | Texas | |
| MD Anderson Cancer Center | Houston | Texas | |
| Joe Arrington Cancer Research Treatment Center | Lubbock | Texas | |
| Huntsman Cancer Institute | Salt Lake City | Utah | |
| University of Virginia | Charlottesville | Virginia | |
| Virginia Commonwealth University - Massey Cancer Center | Richmond | Virginia | |
| Fred Hutchinson Cancer Research Center | Seattle | Washington |
+ 176 more sites — see the full list on the official registry below.
On this site
📄 Darzalex (daratumumab) drug profile →More Janssen Research & Development, LLC trials in Japan
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05455320 on ClinicalTrials.gov ↗ ← All trials in Japan