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Clinical Trials in Italy / NCT07739732
Recruiting Observational

Periodontitis on Gingival Crevicular Fluid Metobolomics

NCT07739732 · tracked via the Priya Life Science Italy tracker
Sponsor
University of Catania
Phase
Observational
Started
2026-05-04
Last updated
2026-07-31

Condition(s) studied

Periodontitis

Investigational drug(s) / intervention(s)

Periodontal probing depth

Periodontal probing depth: Periodontal probing depth measured in millimeters

Study summary

This cross-sectional observational study will compare the gingival crevicular fluid metabolomic profile of 30 adults with periodontitis and 30 periodontally healthy adults. Participants will undergo a periodontal examination and gingival crevicular fluid collection during a single study visit. Targeted metabolomic analysis will be used to identify differences between the two groups and associations with periodontal clinical parameters.

Eligibility

Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
Accepted
Inclusion Criteria: 1. Age between 18 and 70 years. 2. Ability to understand the study procedures and provide written informed consent. 3. For the periodontitis group: diagnosis of periodontitis according to the 2018 classification of periodontal diseases. 4. For the healthy control group: periodontal health according to the 2018 classification, with no current diagnosis or history of periodontitis. Exclusion Criteria: 1. Periodontal treatment during the previous 6 months. 2. Use of antibiotics, non-steroidal anti-inflammatory drugs, or immunosuppressive agents during the previous 6 months. 3. Pregnancy.

Primary outcome measure(s)

  • Probing pocket depth — Baseline

Trial sites (1)

FacilityCityRegionStatus
AOU Policlinico G. Rodolico Catania Italy Recruiting

More University of Catania trials in Italy

Auditory Functions in Patients With Multiple Sclerosis Recruiting
Impact of Non-surgical Periodontal Treatment on Targeted Metabolomics Recruiting
Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis Recruiting
Olfactory and Trigeminal Functions in Patients With Multiple Sclerosis: Case-control Study Starting soon
Analysis of Line-Field Confocal Optical Coherence Tomography (LC-OCT) in Characterization of Gingival Systemic Health, Gingivitis and Periodontitis Enrolling by invitation

Other trials for the same condition

Type I Diabetes and Non-surgical Periodontal Treatment Active, not recruiting
Application of Ultra-high Frequency Ultrasonography (UHFUS) to the Study of Gingival Tissues Recruiting
Diagnostic Accuracy of Oral Images, OPGs, Biomarkers and Questionnaires vs. Clinical Assessment for Periodontal Disease (PostNCT07164573) Recruiting
Powered vs. Manual Toothbrushing in Stage 3-4 Periodontitis Enrolling by invitation
Impact of Non-surgical Periodontal Treatment on Targeted Metabolomics Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07739732 on ClinicalTrials.gov ↗ ← All trials in Italy