Auditory Functions in Patients With Multiple Sclerosis

NCT06164483 · tracked via the Priya Life Science Italy tracker

Sponsor

University of Catania

Phase

Observational

Started

2026-05-11

Last updated

2026-05-12

Condition(s) studied

Multiple SclerosisHearing Disorders

Investigational drug(s) / intervention(s)

Auditory testCSF sampling

Auditory test: The patients will perform: Pure Tone Auditory test + Tympanometry and Stapedial Reflex * Speech Perception test * In case of tinnitus: tinnitus questionnaire and acuphenometry * DPOAEs * ABR

CSF sampling: Cerebrospinal Fluid will be collected by lumbar puncture and analyzed

Study summary

The study will analyze the auditory functions of patients with Multiple Sclerosis using auditory tests like pure tone auditory test, speech perception test, Auditory Brain Response (ABR) and Distortion Product Otoacustic Emission (DPOAE). CSF will be collected by lumbar puncture and analyzed looking for inflammatory markers.

The results of DPOAE and CSF will be correlated to identify statistically significant correlation.

Eligibility

Sex

ALL

Min age

20 Years

Max age

40 Years

Healthy volunteers

Accepted

Inclusion Criteria * age \>18 and \<50, * no history of hearing loss, * no psychiatric condition * no familial history of otosclerosis/deafness/genetic hearing loss * patients with PD and/or MS. Exclusion Criteria * Conductive hearing loss * stroke \< 2 years * cardiovascular disease non under control * diabetes * hypotensive disorders * alcohol abuse * recreational drug consumption * epilepsy

Primary outcome measure(s)

Auditory functions and correlation with CSF findings — 12 months
The worsening of the hearing thresholds and DPOAE results will be correlated with the presence of inflammatory elements in the CSF

Trial sites (1)

Facility	City	Region	Status
Arianna Di Stadio	Catania	Sicily	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06164483 on ClinicalTrials.gov ↗ ← All trials in Italy