Transthoracic echocardiography is an essential imaging modality for the diagnosis and follow-up of cardiovascular diseases. Comprehensive echocardiographic assessment requires multiple quantitative measurements of cardiac structure and function, which are time-consuming and highly dependent on operator expertise. US2.AI (Us2.v1) is an artificial intelligence (deep learning)-based software designed to automatically analyze standard two-dimensional and Doppler echocardiographic DICOM video clips acquired from different ultrasound vendors. The software provides automated measurements of cardiac morphology and function, including chamber dimensions and volumes, left and right ventricular systolic and diastolic function, myocardial strain, and Doppler-derived parameters, generating a comprehensive echocardiographic report based on current international guideline recommendations. In addition, the software may assist in identifying echocardiographic features suggestive of several cardiovascular conditions, including heart failure, pulmonary hypertension, hypertrophic cardiomyopathy, cardiac amyloidosis, valvular heart disease, and ischemic cardiomyopathy.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Adults aged 18 years or older.
* Undergoing clinically indicated standard transthoracic echocardiography.
* Adequate echocardiographic image quality for automated and expert analysis.
* Written informed consent provided prior to study participation.
Exclusion Criteria:
* Age \<18 years.
* Frequent and/or complex cardiac arrhythmias during echocardiographic examination.
* Suboptimal echocardiographic images.
Primary outcome measure(s)
Agreement between AI-derived and expert-derived echocardiographic measurements across predefined patient subgroups — January 2027 Comparison of the agreement between automated and expert-derived measurements in predefined subgroups, including participants with normal echocardiographic findings and those with specific cardiovascular diseases.
Agreement between AI-derived and expert-derived echocardiographic measurements — Jan 2027 Agreement between automated echocardiographic measurements generated by the US2.AI software and manual measurements performed by experienced echocardiographers (reference standard) across standard two-dimensional, Doppler, and strain parameters.
Time required for echocardiographic analysis — January 2027 Comparison of the time required to obtain a complete set of echocardiographic measurements using manual analysis by experienced echocardiographers versus automated analysis by the US2.AI software.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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