GLS in Difficult CPB Weaning

Condition(s) studied

Investigational drug(s) / intervention(s)

Myocardial strain imaging: Two-dimensional strain analysis was performed using frame-by-frame tracking of unique patterns of bright and dark pixels in grayscale (B-mode) sector images to assess myocardial deformation. The frame rate was maintained between 40 and 90 Hz. The myocardium in each image was divided into six myocardial segments, which were individually assessed for tracking quality. GLS was calculated as the average strain value of 18 myocardial segments obtained from the three echocardiographic views. Patients were included in the final analysis if at least 15 out of 18 segments were considered acceptable for strain measurement by the investigator.

Study summary

The goal of this observational study is to learn whether global longitudinal strain (GLS), measured by echocardiography, can predict difficulty separating from cardiopulmonary bypass (CPB) in adults undergoing elective cardiac surgery.

The main questions it aims to answer are:

* Can preoperative GLS measurement predict difficult separation from CPB?
* Are GLS values associated with outcomes such as intensive care unit (ICU) stay, hospital stay, cardiac biomarkers, or 30-day mortality?

Participants will:

* Undergo standard cardiac surgery requiring CPB
* Have echocardiographic assessments (TTE before and after surgery)
* Have their recovery and outcomes monitored, including ICU and hospital stay, postoperative labs, and survival within 30 days

Eligibility

Primary outcome measure(s)

• To evaluate the predictive value of GLS measurements for difficult separation from cardiopulmonary bypass. — perioperative
  Separating from CPB was categorized as easy and difficult separation from CPB. Easy separation from CPB was defined as no pharmacologic support or use of a single agent (either vasoactive or inotropic). Difficult CPB separation can be defined as the need of at least 2 inotropes or vasopressors to successfully accomplish the separation from CPB

Trial sites (2)

Other trials for the same condition