Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact
Recruiting Phase 3

A Study Comparing JNJ-79635322 and Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT07518186 · tracked via the Priya Life Science Italy tracker
Phase
Phase 3
Started
2026-05-31
Last updated
2026-09-25

Condition(s) studied

Multiple Myeloma

Investigational drug(s) / intervention(s)

JNJ-79635322 →Teclistamab →

JNJ-79635322: JNJ-79635322 will be administered as SC injection.

Teclistamab: Teclistamab will be administered as SC injection.

Study summary

The purpose of this study is to evaluate how well JNJ-79635322 works when compared with teclistamab.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion criteria: * Documented diagnosis of multiple myeloma (MM) as defined by the criteria below: a. MM diagnosis according to the international myeloma working group (IMWG) diagnostic criteria, b. Measurable disease at screening as assessed by central laboratory * Received 1 to 3 prior lines of antimyeloma therapy, including an anti-cluster of differentiation (CD) 38 antibody and lenalidomide * Have an eastern cooperative oncology group (ECOG) performance status of 0 to 2 at screening and immediately before the first dose of study medication * Have clinical laboratory values meeting the criteria specified in the protocol during the screening and within 1 day of the start of administration of study treatment Exclusion criteria: * Major surgery, (for example, requiring general anesthesia) or significant traumatic injury within 2 weeks prior to first dose, or will not have fully recovered from surgery, or has surgery planned during the time the participant is expected to participate in the study * Suspected or known allergies, hypersensitivity, intolerance or other contraindications to the use of JNJ-79635322 or teclistamab or their excipients * Presence of any of the following: i. Any ongoing myelodysplastic syndrome or B-cell malignancy (other than MM); ii. Any history of malignancy, other than MM, that is considered at high risk of recurrence requiring systemic therapy; iii. Any active malignancy (that is, progressing or requiring treatment change in the last 24 months) other than MM * Known active or prior central nervous system (CNS) involvement or exhibits clinical signs of meningeal involvement of MM. If either is suspected, negative whole brain magnetic resonance imaging (MRI) and lumbar cytology are required

Primary outcome measure(s)

  • Complete Response (CR) or Better — Up to approximately 41 months
    CR or better is defined as the percentage of participants achieving CR or stringent complete response (sCR) prior to subsequent antimyeloma therapy in accordance with the international myeloma working group (IMWG) criteria during or after the study treatment.
  • Progression-Free Survival (PFS) — Up to approximately 41 months
    PFS is defined as the duration from the date of randomization to either progressive disease (PD) or death, whichever comes first. Disease progression will be determined according to the IMWG response criteria.

Trial sites (173)

FacilityCityRegionStatus
Alabama Oncology Birmingham Alabama Recruiting
Mayo Clinic 1 Phoenix Arizona Recruiting
Highlands Oncology Group Springdale Arkansas Recruiting
Beverly Hills Cancer Center Clinical Research Advisors LLC Beverly Hills California Recruiting
UC Irvine Health Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California Recruiting
Valkyrie Clinical Trials Los Angeles California Recruiting
University of California Irvine Medical Center Orange California Recruiting
Colorado Blood Cancer Institute Denver Colorado Recruiting
University of Connecticut Health Center Farmington Connecticut Recruiting
Mayo Clinic Jacksonville Jacksonville Florida Recruiting
Memorial Cancer Institute Pembroke Pines Florida Recruiting
Emory University Atlanta Georgia Recruiting
Rush University System for Health Chicago Illinois Recruiting
Franciscan Health Indianapolis Indiana Recruiting
University of Iowa Hospitals and Clinics Iowa City Iowa Recruiting
Mission Cancer Blood University of Iowa Health Care Waukee Iowa Recruiting
Norton Cancer Institute Louisville Kentucky Recruiting
LSU Health Feist Weiller Cancer Center Shreveport Louisiana Recruiting
Johns Hopkins Hospital Baltimore Maryland Recruiting
Tufts Medical Center Boston Massachusetts Recruiting
Karmanos Cancer Institute Detroit Michigan Recruiting
University Of Minnesota Medical Center Minneapolis Minnesota Recruiting
Mayo Clinic Rochester Minnesota Recruiting
Nebraska Cancer Specialists Omaha Nebraska Recruiting
Astera Cancer Care East Brunswick New Jersey Recruiting
Christus St. Vincent Regional Cancer Center Santa Fe New Mexico Recruiting
New York Oncology Hematology Albany New York Recruiting
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island Mineola New York Recruiting
NYU Langone Health Manhattan New York New York Recruiting
New York Cancer and Blood Specialists Shirley New York Recruiting
Duke University Medical Center Durham North Carolina Recruiting
Gabrail Cancer Center Canton Ohio Recruiting
The Christ Hospital Cincinnati Ohio Recruiting
Dayton Physicians Network Urology Dayton Ohio Recruiting
Willamette Valley Cancer Institute and Research Center Eugene Oregon Recruiting
Bon Secours Saint Francis Cancer Center Greenville South Carolina Recruiting
Tennessee Oncology, PLLC Nashville Tennessee Recruiting
Baylor University Medical Center Dallas Texas Recruiting
Joe Arrington Cancer Research Treatment Center Lubbock Texas Recruiting
Utah Cancer Specialists Salt Lake City Utah Recruiting

+ 133 more sites — see the full list on the official registry below.

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07518186 on ClinicalTrials.gov ↗ ← All trials in Italy