PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease
Condition(s) studied
Investigational drug(s) / intervention(s)
BI 764198: BI 764198
Placebo matching BI 764198: Placebo matching BI 764198
Study summary
This study is open to adults with certain kidney conditions, including secondary focal segmental glomerulosclerosis (sFSGS), treatment-resistant primary minimal change disease (TR-pMCD), Alport Syndrome (AS), and treatment-resistant primary membranous nephropathy (TR-pMN). Adolescents with treatment-resistant primary MCD can also participate in this study. The purpose of this study is to find out whether a medicine called BI 764198 helps people with these kidney conditions.
Participants are put into 2 groups randomly, which means by chance. One group takes BI 764198 tablets, and the other group takes placebo tablets. Placebo tablets look like BI 764198 tablets but do not contain any medicine. Participants take a tablet once a day for 20 weeks. All participants also continue their standard medication for their kidney condition during the study. Participants have twice the chance of being placed in the BI 764198 group than in the placebo group.
Participants are in the study for about 7 months. During this time, they visit the study site 6 times and have 3 phone calls. Doctors regularly test the protein levels in participants' urine by collecting urine samples. They also check kidney function by taking blood samples. The results are compared between the two groups to see whether the treatment works. The doctors also regularly check participants' health and take note of any unwanted effects.
Eligibility
Primary outcome measure(s)
- Relative change from baseline to Week 20 in 24-hr Urine protein-to-Creatinine Ratio (UPCR) — At baseline and week 20
Trial sites (164)
| Facility | City | Region | Status |
|---|---|---|---|
| Nephrology Consultants, LLC | Huntsville | Alabama | Recruiting |
| Kidney Disease Medical Group | Glendale | California | Recruiting |
| Amicis Research Center - Balboa | Granada Hills | California | Recruiting |
| Academic Medical Research Institute - Glendale | Los Angeles | California | Recruiting |
| University of California Los Angeles | Los Angeles | California | Not Yet Recruiting |
| Colorado Kidney Care | Denver | Colorado | Recruiting |
| Florida Kidney Physicians - Boca Raton | Boca Raton | Florida | Recruiting |
| Florida Kidney Physicians, LLC - Fort Lauderdale | Fort Lauderdale | Florida | Recruiting |
| Total Research Group, LLC | Miami | Florida | Recruiting |
| CTR Oakwater, LLC | Orlando | Florida | Recruiting |
| Florida Kidney Physicians - Riverview/Brandon | Riverview | Florida | Recruiting |
| Ann & Robert H. Lurie Children's Hospital of Chicago | Chicago | Illinois | Not Yet Recruiting |
| Endeavor Health | Evanston | Illinois | Not Yet Recruiting |
| Johns Hopkins Hospital | Baltimore | Maryland | Recruiting |
| St. Clair Nephrology Research, LLC - Shelby Township | Shelby | Michigan | Recruiting |
| New York Nephrology and Dialysis Access Surgery, PC | Clifton Park | New York | Recruiting |
| Queens Long Island Kidney Center | Fresh Meadows | New York | Not Yet Recruiting |
| NYU Langone Nephrology Associates-Mineola | Mineola | New York | Recruiting |
| Duke University Medical Center | Durham | North Carolina | Not Yet Recruiting |
| Cleveland Clinic | Cleveland | Ohio | Not Yet Recruiting |
| Nationwide Children's Hospital | Columbus | Ohio | Not Yet Recruiting |
| Northeast Clinical Research Center | Bethlehem | Pennsylvania | Not Yet Recruiting |
| Southeast Renal Research Institute | Chattanooga | Tennessee | Recruiting |
| Nephrotex Research Group | Dallas | Texas | Not Yet Recruiting |
| Provecta Researh Network | Houston | Texas | Recruiting |
| West Virginia University Medicine | Morgantown | West Virginia | Not Yet Recruiting |
| Terapia Renal Domiciliaria | Buenos Aires | Argentina | Recruiting |
| Centro Medico Dra Laura Maffei | Ciudad Autonoma Buenos Aires | Argentina | Recruiting |
| Clinica Privada Velez Sarfield | Córdoba | Argentina | Recruiting |
| CardioAlem Investigaciones | San Isidro | Argentina | Recruiting |
| Concord Repatriation General Hospital | Concord | New South Wales | Not Yet Recruiting |
| Nepean Hospital | Kingswood | New South Wales | Recruiting |
| John Hunter Hospital | New Lambton Heights | New South Wales | Recruiting |
| Royal Brisbane and Women's Hospital | Brisbane | Queensland | Recruiting |
| Princess Alexandra Hospital | Woolloongabba | Queensland | Recruiting |
| AZORG Ziekenhuis | Aalst | Belgium | Recruiting |
| Hopital Erasme | Brussels | Belgium | Not Yet Recruiting |
| Az Maria Middelares Gent | Ghent | Belgium | Recruiting |
| UZ Leuven | Leuven | Belgium | Recruiting |
| Universidade Federal do Ceara | Fortaleza | Brazil | Recruiting |
+ 124 more sites — see the full list on the official registry below.
More Boehringer Ingelheim trials in Italy
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07355296 on ClinicalTrials.gov ↗ ← All trials in Italy