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Clinical Trials in Italy / NCT06800898
Recruiting Observational

Orexin Gene in Anorexia Nervosa

NCT06800898 · tracked via the Priya Life Science Italy tracker
Sponsor
Istituto Auxologico Italiano
Phase
Observational
Started
2024-06-19
Last updated
2026-03-30

Condition(s) studied

Anorexia Nervosa

Investigational drug(s) / intervention(s)

Blood samples and Questionnaires

Blood samples and Questionnaires: Blood samples for methylation of the promoter of the OX-A and OX-B genes and questionnaires: Eating Disorder Examination Q Eating Disorder Inventory 3 Major Depression Inventory Symptom Checklist-revised ESS - Epworth Sleepiness Scale Pittsburgh Sleep Quality Index Horne \& Ostberg questionnaire

Study summary

The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (\> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Patients with Anorexia Nervosa: Inclusion Criteria: * Female sex * Age 18 years and older * Anorexia Nervosa * Hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy Exclusion Criteria: * Absence of signed informed consent Control group: Inclusion Criteria: * Female sex * Age 18 years and older * Body Mass Index between 18.5 and 24.9 kg/m2 Exclusion Criteria: * Absence of signed informed consent * Presence of any physical and mental pathology

Primary outcome measure(s)

  • Orexin A promoter methylation — Baseline
    Percentage of Orexin A promoter methylation
  • Orexin B promoter methylation — Baseline
    Percentage of Orexin B promoter methylation

Trial sites (1)

FacilityCityRegionStatus
Istituto Auxologico Italiano IRCCS, Site Piancavallo Oggebbio Verbania Recruiting

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Other trials for the same condition

Cognitive Evaluation of Patients With Eating Disorders Recruiting
Amino Acids in Patients With Anorexia Nervosa: Double-blind Randomized Study Versus Placebo Recruiting
AI and VR Devices for Eating Behavior Rehabilitation Recruiting
Virtual Reality Exposure to Reduce Food Related Anxiety in Anorexia Nervosa Recruiting
Intermittent Theta Burst Transcranial Magnetic Stimulation of the Right Parietal Lobe in Anorexia Nervosa Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06800898 on ClinicalTrials.gov ↗ ← All trials in Italy