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Clinical Trials in Italy / NCT05775458
Recruiting Observational

Glutamate Excitotoxicity and Its Role in Glioblastoma Biology

NCT05775458 · tracked via the Priya Life Science Italy tracker
Sponsor
IRCCS San Raffaele
Phase
Observational
Started
2020-06-01
Last updated
2025-06-11

Condition(s) studied

Brain Tumor, Primary

Investigational drug(s) / intervention(s)

Blood, CSF and tumor samples

Blood, CSF and tumor samples: Blood, CSF and brain tissue sampling of Glu and Glu regulatory proteins.

Study summary

Gliomas are the most frequent type of primary brain tumors in adults; among them glioblastoma multiforme (GBM) is the most malignant, being associated with the worst prognosis. Glutamate (Glu) is an aminoacid, responsible for essential functions in the Central Nervous System (CNS), acting both as metabolite and neurotransmitter. It is essential for regulating cellular metabolism and developmental synaptogenesis, cellular migration, differentiation and death. Recent scientific evidences have demonstrated alteration in Glu synthesis and signaling being directly involved in GBM growth and invasion

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Adult patients with a brain lesion suspected for GBM, candidate to gross total tumor resection (GTR), followed by radiotherapy and chemotherapy (concomitant and adjuvant). * Patient able to provide informed consent. Exclusion Criteria: * Age \< 18 years * Liver disease * Severe anemia (Hb \<8mg/dl) * Pregnancy

Primary outcome measure(s)

  • Baseline characterization of Glutamate scavengers (Glu-sca) levels in serum — Baseline (before surgery)
    Serum GOT1 (UI/ml), GPT (UI/ml)
  • Baseline characterization of Glutamate (Glu) levels in serum — Baseline (before surgery)
    Serum Glutamate (μM/L)
  • Time changes in Glutamate scavengers (Glu-sca) levels in serum — At 3, 6, 9 months following surgery
    Serum GOT1 (UI/ml), GPT (UI/ml)
  • Time changes in Glutamate (Glu) levels in serum — At 3, 6, 9 months following surgery
    Serum Glutamate (μM/L)

Trial sites (1)

FacilityCityRegionStatus
IRCCS San Raffaele Scientific Institute Milan Milan Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05775458 on ClinicalTrials.gov ↗ ← All trials in Italy