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Clinical Trials in Italy / NCT05715203
Recruiting Observational

Aortic Stiffness in Patients With Genetic Aortopathies

NCT05715203 · tracked via the Priya Life Science Italy tracker
Sponsor
IRCCS Policlinico S. Donato
Phase
Observational
Started
2023-02-15
Last updated
2025-09-10

Condition(s) studied

Rare DiseasesAortic StiffnessConnective Tissue Defect

Investigational drug(s) / intervention(s)

Pulsotonometry

Pulsotonometry: Evaluation of arterial stiffness

Study summary

The goal of this observational study is to study arterial stiffness in patients with thoracic ascending aortic aneurysms (TAA), either syndromic or non-syndromic. The main questions it aims to answer are:

* Stratification of aortic risk based on arterial stiffness; Compare measurements with morphological and haemodynamic features of the ascending thoracic aorta.

Participants will be asked to undergo non-invasive evaluation of blood pressure and arterial stiffness.

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Subjects with AAT, either syndromic or non syndromic; * Signed informed consent Exclusion Criteria: * Patients with early menopause and/or osteoporosis, rheumatic heart disease and active malignant tumours; * Patients with acute and chronic inflammatory conditions such as: chronic liver disease, chronic renal insufficiency and diseases affecting the thyroid system; * Seropositivity to HIV, HCV, HBsAg and SARS-CoV-2; * Pregnancy

Primary outcome measure(s)

  • Pulse Wave Velocity — 18 months
    Statistic analysis will be performed using the Statistical Package for Social Science (SPSS for Windows; v20.0; SPSS, Chicago, Illinois, USA). Continuous variables will be expressed as mean ± Standard Deviation, while qualitative variables will be expressed as a percentage. Qualitative data will be compared using Fisher's test or Pearson's χ2 test, when appropriate. Continuous variables by t-test or analysis of variance normalized for covariates. Continuous variables will be correlated by simple or multiple linear regression

Trial sites (1)

FacilityCityRegionStatus
IRCCS Policlinico San Donato San Donato Milanese Lombardy Recruiting

More IRCCS Policlinico S. Donato trials in Italy

GenLab: Unveiling the Genetic Landscape of Brugada Syndrome: Novel Biomarker Discovery for Precise Diagnosis Recruiting
Analysis of Muscular Properties in Patients With MFS and EDS Active, not recruiting
Phenotyping Left Ventricle Failure With Hemodynamic Biomarkers From 4D Flow Magnetic Resonance Imaging Recruiting
Impact of Prontosan Wound Gel X on Surgical Site Infections in Cardiac Surgery Recruiting
Estimation of Cardiovascular Risk in Patients With Crohn's Disease and Ulcerative Colitis (PROVACI) Enrolling by invitation

Other trials for the same condition

Analysis of Muscular Properties in Patients With MFS and EDS Active, not recruiting
Genomic Profiling of Genetic and Rare Diseases Recruiting
Longitudinal Study of Ultra-rare Inherited Metabolic and Degenerative Neurological Diseases. Recruiting
PREcision Diagnostics in Rare genetIC Diseases and Tumors - Long Read Sequencing Recruiting
Investigation of the Neurovegetative Pattern in Patients With Thoracic Aortic Aneurysms (TAA) Active, not recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05715203 on ClinicalTrials.gov ↗ ← All trials in Italy