🇮🇪Ireland
16°C Partly Cloudy · Dublin
Live Updates
--:--:-- IST
Contributor sign in
Latest
Ireland Needs 46,000 More Digital Specialists by 2030, EGFSN Report Warns ◆ Project Management Failures: Lessons for Healthcare ◆ FDA Approves Lilly's Weekly Insulin Onswik to Rival Awiqli ◆ WeBuild Programme: 50+ Women-Led Ventures and How to Apply ◆ Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity ◆ Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing ◆ Ireland Needs 46,000 More Digital Specialists by 2030, EGFSN Report Warns ◆ Project Management Failures: Lessons for Healthcare ◆ FDA Approves Lilly's Weekly Insulin Onswik to Rival Awiqli ◆ WeBuild Programme: 50+ Women-Led Ventures and How to Apply ◆ Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity ◆ Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing ◆
Clinical Trials in Italy / NCT05703893
Active, not recruiting Observational

Investigation of the Neurovegetative Pattern in Patients With Thoracic Aortic Aneurysms (TAA)

NCT05703893 · tracked via the Priya Life Science Italy tracker
Sponsor
IRCCS Policlinico S. Donato
Phase
Observational
Started
2021-11-09
Last updated
2025-09-10

Condition(s) studied

Rare DiseasesAortic Aneurysm, Thoracic

Investigational drug(s) / intervention(s)

Supine resting (REST) and active standing (STAND)

Supine resting (REST) and active standing (STAND): Analysis of baroreflex sensitivity

Study summary

The goal of this observational cross-sectional study is to learn about vagal features in patients with syndromic and non-syndromic TAA. The main question it aims to answer is to highlight a functional condition that could help stratify patients with TAA on the risk of aortic complications.

Participant will take part by standing in supine position for 10 minutes and during active standing for 10 minutes. In this period of time, it will be possible to acquire the signals continuously and non invasively through recorded non-invasive blood pressure and piezoelectric sensor breathing belt.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria: * Patients aged 18-65 years with syndromic and nonsyndromic TAA; * Signed informed consent; * Patients on regular pharmacological prophylaxis (with Losartan) or naïve patients with a first diagnosis Exclusion Criteria: * Acute and chronic inflammatory diseases such as: liver disease, chronic renal insufficiency (creatinine \> 1.5 mg/dl) and diseases affecting the thyroid system.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
IRCCS Policlinico San Donato San Donato Milanese Lombardy

More IRCCS Policlinico S. Donato trials in Italy

Fibroblast Line Evaluation for COL5A eXpression and Thoracic Aortic Aneurysms: in Vitro Characterization of Cutaneous Fibroblasts in Adult Patients Recruiting
Fatigue Behavior of Peripheral STENt of the Superficial Femoral Artery Active, not recruiting
RNA as Prognostic Biomarkers in Patients With Acute Coronary Syndrome Recruiting
The Signature of Alzheimer's Disease in Subjective Cognitive Decline Recruiting
Pain Control After Aortic EndoaneurYsmEctomy (POPEYE) Recruiting

Other trials for the same condition

Gait and Balance Impairment in Rare and Very Rare Neurological Diseases Recruiting
REgistRy BRAnch goRE EndopRosthEsis Starting soon
Analysis of Muscular Properties in Patients With MFS and EDS Active, not recruiting
Fibroblasts and Thoracic Aortic Aneurysms: in Vitro Characterization in With Marfan Syndrome and Genetic Aortic Diseases Enrolling by invitation
Longitudinal Study of Ultra-rare Inherited Metabolic and Degenerative Neurological Diseases. Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05703893 on ClinicalTrials.gov ↗ ← All trials in Italy