Impact of Stress CT Myocardial Perfusion on Downstream Resources and Prognosis

Condition(s) studied

Investigational drug(s) / intervention(s)

Integration of CCTA with stress CTP when indicated: When judged indicated, functional assessment with stress CTP perfusion will be performed on top of CCTA.

Standard of care approach: (a) functional non-invasive tests (stress ECG, or imaging-based tests such as Stress Echo, Stress CMR, SPECT or PET) as a gatekeeper for ICA; (b) direct referral to ICA.

Study summary

CT myocardial perfusion imaging (CTP) represents one of the newly developed CT-based techniques but its cost-effectiveness in the clinical pathway is undefined. The aim of the study is to evaluate the usefulness of combined evaluation of coronary anatomy and myocardial perfusion in intermediate to high-risk patients for suspected CAD or with known disease in terms of clinical decision-making, resource utilization and outcomes in a broad variety of geographic areas and patient subgroups.

Eligibility

Primary outcome measure(s)

• Reclassification rate of CCTA in group B due to the addition of CTP — 30 days.
  For each enrolled patient in whom both CCTA and stress CTP will be performed, the endpoint review committee will use data from coronary CTA and CTP, along with the clinical data to determine the management plan using the following criteria: (a) optimal medical therapy, (b) more non-invasive information required, (c) invasive evaluation required, (d) revascularization treatment (PCI or CABG or hybrid treatment).

Trial sites (1)

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