A Study of PARP1 Selective Inhibitor, EIK1004 (IMP1707) in Participants With Advanced Solid Tumors.
Condition(s) studied
Investigational drug(s) / intervention(s)
EIK1004-001 (IMP1707-001): PARP1 selective inhibitor
Study summary
This study will evaluate the safety, tolerability, and preliminary efficacy of EIK1004 (IMP1707) in participants with recurrent advanced/metastatic breast cancer, ovarian cancer, metastatic castrate resistant prostate cancer (mCRPC) and pancreatic cancer with deleterious/suspected deleterious mutations of select homologous recombination repair (HRR) genes.
Condition or disease Intervention/treatment Phase Advanced Solid Tumors Drug: EIK1004 (IMP1707) Phase 1/Phase 2
Eligibility
Primary outcome measure(s)
- Number of Participants who experience a Dose-Limiting Toxicity (DLT) — (Timeframe: up to 28 days)
A DLT is defined as an event with toxicity including the type, severity, time of onset, time of resolution, and the probable association with study treatment that are not due to pre-existing conditions as defined by the Common Terminology Criteria for Adverse Events Version 5.0 (CTCAE 5.0). The number of participants who experience a DLT will be reported. - Number of participants with adverse events, treatment emergent adverse events or serious adverse events — (Time Frame: 1 month post last dose of EIK1004 (IMP1707)
Number of participants reporting adverse events or serious adverse events which include any abnormal clinical events, laboratory assessments outside of normal clinical range, abnormal vital signs observed, and any abnormal ECG parameters
Trial sites (10)
| Facility | City | Region | Status |
|---|---|---|---|
| Sarah Cannon Research Institute at HealthOne | Denver | Colorado | Recruiting |
| Florida Cancer Center | Lake Mary | Florida | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | Recruiting |
| MD Anderson | Houston | Texas | Recruiting |
| NEXT Oncology | San Antonio | Texas | Recruiting |
| NEXT Virginia | Fairfax | Virginia | Recruiting |
| PASO Medical | Frankston | Victoria | Recruiting |
| Chongqing University Cancer Hospital | Chongqing | Chongqing Municipality | Recruiting |
| Cancer Hospital of Shandong First Medical University(Shandong Cancer Institute, Shandong Cancer Hospital) | Jinan | Shandong | Recruiting |
| Fudan University Shanghai Cancer Center | Shanghai | China | Recruiting |
More Eikon Therapeutics trials in Israel
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06907043 on ClinicalTrials.gov ↗ ← All trials in Israel