Cerebellar Modulation of Cognition in Psychosis
Condition(s) studied
Investigational drug(s) / intervention(s)
intermittant theta burst stimulation (iTBS): iTBS consists of 2 s trains of 3 pulses at 50 Hz, repeated at 5 Hz, every 10s for a total of 600 pulses.
continuous theta burst stimulation (cTBS): cTBS consists of 3 pulses at 50 Hz repeated at 5 Hz (every 200ms) continuously for a total of 600 pulses
sham rTMS: sham rTMS does not deliver a significant change in magnetic field strength
Study summary
The goal of this clinical trial is to learn about cognition in psychotic disorders (schizophrenia, bipolar disorder, and schizoaffective disorder). The main question it aims to answer is: Can we use magnetic stimulation to change processing speed (how quickly people can solve challenging tasks).
Participants will be asked to perform cognitive tasks (problem-solving) and undergo brain scans before and after transcranial magnetic stimulation (TMS). TMS is a way to non-invasively change brain activity. Forms of TMS are FDA-approved to treat depression and obsessive compulsive disorder. In this study, we will use a different form of TMS to temporarily change brain activity to observe how that changes speed in problem-solving.
Eligibility
Primary outcome measure(s)
- BACS Symbol Coding test — eight minutes before TMS and one minute after TMS on each of the three TMS visit days
The BACS Symbol coding test is a test of information processing speed - BACS Digit Sequence test — five minutes before TMS and four minutes after TMS on each of the three TMS visit days
The BACS digit sequence test is a test of working memory performance - functional Magnetic Resonance Imaging — fifteen minutes before TMS and nine minutes after TMS on each of the three TMS visit days
resting-state (task free) functional connectivity
Trial sites (2)
| Facility | City | Region | Status |
|---|---|---|---|
| McLean Hospital | Belmont | Massachusetts | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | Recruiting |
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06107764 on ClinicalTrials.gov ↗ ← All trials in Israel