A Study of JNJ-90009530 in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (r/r B-NHL)
Condition(s) studied
Investigational drug(s) / intervention(s)
JNJ-90009530: JNJ-90009530, an autologous Chimeric Antigen Receptor (CAR) - T therapy targeting CD20
Study summary
The goal of this multicenter study is to test JNJ-90009530 in Relapsed or Refractory Non-Hodgkin Lymphoma Patients. The main questions the study aims to answer are:
* can a dose of JNJ-90009530 be determined that is safe and well tolerated by patients.
* will JNJ-90009530 help patients achieve a response and for how long?
Eligibility
Primary outcome measure(s)
- Calculate the Occurence of Adverse Events — up to 24 months
The safety and tolerability will be measured by recording the occurence and severity of all adverse events or dose limiting toxicities that occur according to Common Terminology Criteria for Adverse Events (CTCAE) criteria version 5.0 - Determine Recommended Phase 2 dose (RP2D) — up to 24 months
Employ a Bayesian optimal interval (BOIN) design and determine the RP2D with review of the number of dose-limiting toxicities
Trial sites (15)
| Facility | City | Region | Status |
|---|---|---|---|
| University of Iowa Hospital | Iowa City | Iowa | |
| University of Kentucky | Lexington | Kentucky | |
| Mayo Clinic Rochester | Rochester | Minnesota | |
| Rutgers University | New Brunswick | New Jersey | |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | |
| University of Pennsylvania | Philadelphia | Pennsylvania | |
| MD Anderson Cancer Center | Houston | Texas | |
| Royal Prince Alfred Hospital | Camperdown | Australia | |
| Monash Medical Centre | Clayton | Australia | |
| Austin Hospital | Heidelberg | Australia | |
| Royal Brisbane and Women's Hospital | Herston | Australia | |
| Westmead Hospital | Westmead | Australia | |
| Hadassah Medical Center | Jerusalem | Israel | |
| Sheba Medical Center | Ramat Gan | Israel | |
| University College London Hospitals | London | United Kingdom |
More Janssen Research & Development, LLC trials in Israel
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05784441 on ClinicalTrials.gov ↗ ← All trials in Israel