Effect of Cannabis Extract on Acute Radicular Pain and on Analgesic Requirement

Condition(s) studied

Investigational drug(s) / intervention(s)

Single-dose of cannabis oil: Single-dose of cannabis oil in order to treat acute radicular pain

Control: Giving a sub-linguistic olive oil that is similar in appearance and taste to cannabis oil

Study summary

Clinical evidence about the effects of cannabis in the management of acute pain is rather scarce, mostly consisting of case report-based opinions on adverse events during or after general anesthesia after smoking cannabis, experimental pain trials in healthy volunteers, and a few clinical trials using different drugs, dosages and routes of administration. It is difficult to draw strong conclusions from the available evidence, that may seem sometimes even contradictory, mainly due -the investigators believe- to the many sources of variability in the study designs (e.g.: heterogeneity of the study samples, underpowered, unblinding, lack of randomization, timing of the therapeutic intervention, different experimental pain models, inclusion of different kind of surgical pain, etc.). Nevertheless, expert's opinion after a critical review of the literature is that cannabis and cannabinoids may have a beneficial role in the management of acute pain, at least for a selected group of patients and through an appropriate therapeutic intervention.

Cannabis oil seem to be most suitable to our investigation. The co-administration of tetrahydrocannabinol (THC) with cannabidiol (CBD) may translate into additional therapeutic benefits with an attenuation of adverse effects. And will help treat acute radicular back pain and for renal colic.

Eligibility

Primary outcome measure(s)

• opioid consumption via - Patient controlled administration (PCA) — The change over 24 hours
  Count of patient-controlled analgesia pushes.

Trial sites (1)

More Hadassah Medical Organization trials in Israel