Development of Anti-Diabetic Nutraceuticals From Legume Seed Coats

Condition(s) studied

Investigational drug(s) / intervention(s)

Legumes seed soup: The pre-processed seed coats of legumes (Vigna mungo or Macrotyloma uniflorum) are boiled to obtain extracts, combined with varying amounts of cooked cotyledons, and seasoned with salt and spices.

Study summary

This open-label clinical trial aims to evaluate whether daily consumption of soup prepared from boiled water extracts of selected legume seed coats, seasoned with salt and spices, improves glycemic regulation in individuals with metabolic syndrome or type 2 diabetes mellitus (T2DM). The primary question is whether daily intake of this palatable legume-based soup enhances glycemic control. Secondary questions include whether it reduces dyslipidemia, oxidative stress, and inflammation in participants with metabolic syndrome or T2DM. Participants will consume the soup once daily for 30 consecutive days. Clinical assessments, including HbA1c, fasting blood glucose, lipid profile, and biomarkers of oxidative stress and inflammation will be conducted at baseline and after the 30-day intervention.

Eligibility

Primary outcome measure(s)

• Change from baseline in Fasting blood glucose and HbA1c at 4 weeks — Baseline and 4th week
  Fasting blood glucose and plasma HbA1c measured at clinical biochemistry diagnostic laboratory.
• Change from baseline in capillary blood glucose levels after meal at 2 and 4 week — Baseline, 2nd week and 4th week
  Capillary blood glucose levels at baseline, 30 min, 60 min, 90 min and 120 min after a meal by glucometer

Trial sites (1)

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