The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect

NCT06058585 · tracked via the Priya Life Science India tracker

Sponsor

The George Institute

Phase

Phase 3

Started

2024-09-04

Last updated

2026-04-01

Condition(s) studied

Chronic Kidney Diseases

Investigational drug(s) / intervention(s)

FinerenonePlacebo Finerenone

Finerenone: Finerenone 10mg or 20mg tablets, oral, once daily

Placebo Finerenone: Finerenone matched placebo tablets, oral, once daily

Study summary

CAPTIVATE is an international, multi-centre, Phase III, adaptive, platform, randomised controlled trial in people with chronic kidney disease (CKD).

CAPTIVATE aims to find the best treatment, or combination of treatments, that slow the progression of CKD so that fewer people develop kidney failure.

CAPTIVATE provides a research platform that allows many treatment-related questions to be answered within a common trial set-up.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: 1. Age ≥ 18 years 2. Known chronic kidney disease from any cause (eGFR ≥25 mL/min/1.73m2) 3. Currently receiving standard of care treatment according to treating physician 4. Eligible for randomisation in at least one recruiting domain-specific appendix 5. Participant and treating physician are willing and able to perform trial procedures Exclusion Criteria: 1. Planned to commence kidney replacement therapy or kidney transplant surgery in next 6 months 2. Life expectancy less than 6 months

Primary outcome measure(s)

eGFR slope — From randomisation to week 108
eGFR slope calculated using eGFR values from randomisation to week 108

Trial sites (43)

Facility	City	Region	Status
The Canberra Hospital	Garran	Australian Capital Territory	Recruiting
Nepean Blue Mountains Local Health District	Kingswood	New South Wales	Recruiting
St George Hospital	Kogarah	New South Wales	Recruiting
John Hunter Hospital	New Lambton Heights	New South Wales	Recruiting
Westmead Hospital	Westmead	New South Wales	Recruiting
Sunshine Coast Hospital and Health Service	Birtinya	Queensland	Recruiting
Townsville University Hospital	Douglas	Queensland	Recruiting
West Moreton Hospital & Health Service	Ipswich	Queensland	Recruiting
Gold Coast Hospital and Health Service	Southport	Queensland	Recruiting
Royal Adelaide	Adelaide	South Australia	Recruiting
Lyell McEwin Hospital	Elizabeth Vale	South Australia	Recruiting
Austin Health	Heidelberg	Victoria	Recruiting
South Metropolitan Health Service, Fiona Stanley Hospital	Murdoch	Western Australia	Recruiting
Gitam Institute of Medical Sciences and Research	Visakhapatnam	Andhra Pradesh	Recruiting
Patna Medical College and Hospital	Patna	Bihar	Recruiting
DKS Super Speciality Hospital, Raipur	Raipur	Chhattisgarh	Recruiting
Mysore Medical College	Dehradun	Dehradun	Recruiting
GCS Medical College, Hospital & Research Centre	Ahmedabad	Gujarat	Recruiting
Father Muller Medical College Hospital	Mangaluru	Karnataka	Recruiting
Dr Moopen's Medical College	Meppādi	Kerala	Recruiting
CARE-CHL Hospital	Indore	Madhya Pradesh	Recruiting
Medway Hospital	Chennai	Tamil Nadu	Recruiting
Yashoda Hospital Hitec City	Hyderabad	Telangana	Recruiting
Apollo Hospitals	Hyderabad	Telangana	Recruiting
Charak Hospital and Research Centre	Lucknow	Uttar Pradesh	Recruiting
Shri Guru Ram Rai Medical College and Shri Mahant Indiresh Hospital	Dehradun	Uttarakhand	Recruiting
Fortis Hospital	Kolkata	West Bengal	Recruiting
North Bengal Medical College & Hospital	Siliguri	West Bengal	Recruiting
Max Superspeciality Hospital, Dehradun	Dehradun	India	Recruiting
Health New Zealand, Te Whatu Ora Te Matau a Maui, Hawke's Bay Hospital	Hastings	Hawkes Bay	Recruiting
Health New Zealand, Te Whatu Ora Waitemata, North Shore Hospital	Auckland	New Zealand	Recruiting
Auckland City Hospital	Auckland	New Zealand	Recruiting
Aotearoa Clinical Trials Trust, Middlemore Hospital	Auckland	New Zealand	Recruiting
201 Great King Street, Central Dunedin, Dunedin 9016, New Zealand	Dunedin	New Zealand	Recruiting
Private Bag 9742 Maunu Road, Horahora, Whangārei 0148, New Zealand	Whangarei	New Zealand	Recruiting
Hospital Clinico Universitario València (INCLIVA)	Valencia	Espana	Recruiting
National Nephrology Specialized Hospital	Colombo	Polonnaruwa	Recruiting
National Hospital of Sri Lanka	Colombo	Sri Lanka	Recruiting
Kandy National Hospital	Kandy	Sri Lanka	Recruiting
Kurunegala Teaching Hospital	Kurunegala	Sri Lanka	Recruiting

+ 3 more sites — see the full list on the official registry below.

Other trials for the same condition

Pathogenesis of Chronic Kidney Disease Associated With Metabolic Dysfunction- Associated Fatty Liver Disease (MAFLD) and Treatment Response of Oral Semaglutide. Starting soon

A Post Marketing Surveillance to Evaluate the Safety of Desidustat for the Treatment of Anemia in Subjects With Chronic Kidney Disease (CKD).(Real World Evidence Study) Recruiting

Safety and Efficacy of Finerenone in Metabolic Dysfunction Associated Steatotic Liver Disease(MASLD/NAFLD) Related Cirrhosis Patients With Ascites in Prevention of Chronic Kidney Disease. Starting soon

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06058585 on ClinicalTrials.gov ↗ ← All trials in India