Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide The €100K Reality Check: Why a Six-Figure Pharma Salary in Ireland Feels Different Than in Switzerland or Germany Ireland's €93.8 Billion Non-EU Pharma Export Engine: Trade Data, Destination Markets, and Economic Impact
Starting soon Phase 3

A Study of EloraTZP in Adult Participants With Obesity or Overweight and Type 2 Diabetes

NCT07881458 · tracked via the Priya Life Science Germany tracker
Phase
Phase 3
Started
2026-11
Last updated
2026-10-19

Condition(s) studied

ObesityOverweightDiabetes Mellitus, Type 2

Investigational drug(s) / intervention(s)

eloralintide and tirzepatide →Tirzepatide →

eloralintide and tirzepatide: Administered SC

Tirzepatide: Administered SC

Study summary

The purpose of this study is to investigate the efficacy and safety of eloralintide and tirzepatide coformulation (EloraTZP) compared to tirzepatide for body weight reduction in participants with obesity or overweight and type 2 diabetes.

Participation in the study will last about 2 years.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Have type 2 diabetes * Have a stable self-reported body weight (\<5% body weight change) for 90 days prior to screening * Have a BMI of ≥27 kg/m2 at screening * Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity and/or type 2 diabetes (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes * Have taken any of the following within 90 days prior to screening * medications with direct amylin, glucagon-like peptide-1 (GLP-1) or glucagon-dependent insulinotropic polypeptide (GIP) receptor activity, including compounded therapies * dipeptidyl peptidase 4 (DPP-4) inhibitors, and * insulin * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure * Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Primary outcome measure(s)

  • Percent Change from Baseline in Body Weight — Baseline, Week 100

Trial sites (75)

FacilityCityRegionStatus
Tucson Clinical Research Institute Tucson Arizona
Pacific Clinical Studies Inc. Los Alamitos California
Los Angeles Institute for Metabolic Research Los Angeles California
University of Colorado Anschutz Medical Campus Aurora Colorado
American Research Centers of Florida Pembroke Pines Florida
Encore Medical Research - Weston Weston Florida
Care Access - Dalton - Clinical Trials Center by Walmart & Care Access Dalton Georgia
Pacific Diabetes & Endocrine Center Honolulu Hawaii
DM Clinical Research - Indianapolis Indianapolis Indiana
Care Access - Eunice Eunice Louisiana
Tandem Clinical Research Marrero Louisiana
Care Access - St. Louis St Louis Missouri
IMA Clinical Research Warren Warren Township New Jersey
NYC Research New York New York
IMA Clinical Research NYC Midtown New York New York
IMA Clinical Research Austin Austin Texas
Diabetes and Thyroid Center of Ft. Worth Fort Worth Texas
Juno Research Houston Texas
Care Access - Houston - Clinical Trials Center by Walmart & Care Access Houston Texas
ERA Health Research-Texas Midland Texas
Texas Valley Clinical Research (TVCR) - Mission Mission Texas
IMA Clinical Research San Antonio San Antonio Texas
Care Access - Tyler - Clinical Trials Center by Walmart & Care Access Tyler Texas
Washington Center for Weight Management and Research Arlington Virginia
Eastside Research Associates Redmond Washington
Centro de Pesquisa Sao Lucas Campinas Brazil
Cline Research Center Curitiba Brazil
Núcleo de Pesquisa Clínica do Rio Grande do Sul Porto Alegre Brazil
IBPClin - Instituto Brasil de Pesquisa Clínica Rio de Janeiro Brazil
CPCLIN São Paulo Brazil
CEPIC - Centro Paulista de Investigação Clínica São Paulo Brazil
The Second Hospital of Jilin University Changchun China
Jinan Central Hospital Jinan China
The First Affiliated Hospital of Henan University of Science &Technology Luoyang Shi China
The Second Affiliated Hospital of Nanjing Medical University Nanjing China
Ningbo First Hospital Ningbo China
The First Hospital of Hebei Medical University Shijiazhuang China
Tianjin Medical University Zhu Xianyi Memorial Hospital Tianjin China
StudyPoint Duisburg Duisburg Germany
Diabetes Zentrum Wilhelmsburg Hamburg Germany

+ 35 more sites — see the full list on the official registry below.

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07881458 on ClinicalTrials.gov ↗ ← All trials in Germany