The Impact of a Dietary Fiber Enriched Diet on the Outcome of Patients with Liver Cirrhosis
Condition(s) studied
Investigational drug(s) / intervention(s)
Dietary intervention: The aim of the dietary intervention is the implementation of a fiber-enriched diet. Therefore, patients receive dietary counseling, supplemented with propionate, that functions as fiber-surrogate.
Study summary
The goal of this dietary intervention is to study the impact of a dietary fiber enriched diet on the intestinal dysbiosis, systemic inflammation and cirrhosis-related complications in patients with liver cirrhosis.
Therefore, our aim is to investigate the impact of a dietary fiber enriched diet on
* frailty and sarcopenia
* systemic inflammation
* microbiome composition
* quality of life and the composition of patients diet.
Participants receive a dietary counselling and will be asked to increase their dietary fiber intake. As malnutrition is a common complication in cirrhosis and patients with advanced liver disease often show a disability to meet their daily food-requirements, the recommended intake of 30 gram dietary fibers per day is unlikely in this group of patients. Therefore, the fiber-enriched diet will be supplemented by the physiological short-chain-fatty-acid propionate, as a fiber-surrogate.
Eligibility
Primary outcome measure(s)
- Change of the Liver Frailty Index — The Liver Frailty Index will be measured at each study visit (Baseline, after 2 month and after 5 month)
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Hannover Medical School (MHH) | Hanover | Lower Saxony |
More Hannover Medical School trials in Germany
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06634186 on ClinicalTrials.gov ↗ ← All trials in Germany