Ireland
--:--IST
Recruiting Phase 3

Refining Adjuvant Treatment IN Endometrial Cancer Based On Molecular Features

NCT05255653 · tracked via the Priya Life Science Germany tracker
Phase
Phase 3
Started
2021-11-11
Last updated
2026-10-08

Condition(s) studied

Endometrial Cancer

Investigational drug(s) / intervention(s)

Pelvic external beam radiotherapyChemotherapyDurvalumab →Vaginal brachytherapy

Pelvic external beam radiotherapy: 45.0-48.6 Gy; 1.8-2.0 Gy per fraction, 5 fractions a week

Chemotherapy: Preferably concurrent and adjuvant according to the PORTEC-3 schedule: two cycles of intravenous cisplatin 50mg/m² in the first and fourth week of the pelvic external beam radiotherapy followed by four cycles of intravenous carboplatin AUC 5 and paclitaxel 175 mg/m² at 21-day intervals.

Durvalumab: 1500 mg intravenous once every 4 weeks for in total 1 year (13 cycles) starting within the first week of radiotherapy,

Vaginal brachytherapy: Vaginal brachytherapy is to be considered in patients with documented cervical stromal involvement and/or substantial LVSI. Brachytherapy is given with a vaginal cylinder or vaginal ovoids or ring applicator, according to the center's standard technique. When using a cylinder, the active length will ideally be 2-3 cm, with the reference isodose covering the proximal 2.5-3 cm of the vagina. High-dose-rate (HDR) and pulse-dose-rate (PDR) schedules are permitted, which deliver an EQD2 equivalent dose of 10-14 Gy at 5 mm from the vaginal mucosa (to obtain a cumulative EDQ2 of 60 Gy at 5 mm).

Study summary

RAINBO MMRd-GREEN is an international, multicenter, phase III randomised trial wherein adjuvant pelvic external beam radiotherapy combined with and followed by durvalumab for one year is compared to adjuvant pelvic external beam radiotherapy with or without chemotherapy.

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Participants of the four RAINBO trials should be eligible according to the inclusion and exclusion criteria of both the overarching RAINBO trials program and the clinical trial that they are assigned to based on the molecular profile. Inclusion Criteria of the overarching RAINBO program: * Histologically confirmed diagnosis of endometrial cancer (EC) of the following histotypes: endometrioid endometrial carcinoma, serous endometrial carcinoma, uterine clear cell carcinoma, dedifferentiated and undifferentiated endometrial carcinoma, uterine carcinosarcoma and mixed endometrial carcinomas of the aforementioned histotypes. * Full molecular classification performed following the diagnostic algorithm described in WHO 2020 (5th Edition, IARC, Lyon, 2020) * TLH-BSO or TAH-BSO with or without lymphadenectomy or sentinel node biopsy, without macroscopic residual disease after surgery * No distant metastases as determined by pre-surgical or post-surgical imaging (CT/MRI scan of chest, abdomen and pelvis or PET-CT scan) * Age ≥ 18 years * Expected start of adjuvant treatment (if applicable) within 10 weeks after surgery * Patients must be accessible for treatment and follow-up * Written informed consent for participation in one of the RAINBO trials, permission for the contribution of a tissue block for translation research and permission for the use and sharing of data for the overarching research project according to the local Ethics Committee requirements. Exclusion Criteria overarching RAINBO program: * History of another primary malignancy, except for non-melanoma skin cancer, in the past 5 years * Prior pelvic radiation The MMRd-GREEN trial Inclusion criteria: * Written informed consent * WHO Performance score 0-1 * Histologically confirmed FIGO 2009 stage IB/II with LVSI, stage III, or stage IV with limited pelvic peritoneal involvement (FIGO 2023 stage IB with LVSI, stage II with myometrial or cervical stroma involvement and LVSI, or stage III disease) * Molecular classification: MMRd EC\* * No prior pelvic radiotherapy * Body weight \> 30 kg * Adequate systemic organ function: * Creatinine clearance (\> 40 cc/min): Measured creatinine clearance (CL) \>40 mL/min or Calculated creatinine CL\>40 mL/min by the Cockcroft-Gault formula (Cockcroft and Gault 1976) or by 24-hour urine collection for determination of creatinine clearance. * Adequate bone marrow function : hemoglobin \>9.0 g/dl, Absolute neutrophil count (ANC) ≥1.0 x 109/l, platelet count ≥75 x 109/l. * Adequate liver function: Bilirubin ≤1.5 x institutional upper limit of normal (ULN). \<\<This will not apply to patients with confirmed Gilbert's syndrome (persistent or recurrent hyperbilirubinemia that is predominantly unconjugated in the absence of hemolysis or hepatic pathology), who will be allowed only in consultation with their physician.\>\> * ALT (SGPT) and/or AST (SGOT) ≤2.5 x ULN Exclusion criteria: * Major surgical procedure (as defined by the Investigator) within 28 days prior to the first dose of Investigational medicinal product (IMP). * History of allogenic organ transplantation. * Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, interstitial lung disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirement, substantially increase risk of incurring AEs or compromise the ability of the patient to give written informed consent. * Any previous treatment with a PD(L)1 inhibitor, including durvalumab. * Receipt of live attenuated vaccine within 30 days prior to the first dose of durvalumab. Note: Patients, if enrolled, should not receive live vaccine whilst receiving IP and up to 30 days after the last dose of IMP. * Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab with the exceptions of : * Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection). * Systemic corticosteroids at physiologic doses not to exceed \<\<10 mg/day\>\> of prednisone or its equivalent. * Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication). * History of active primary immunodeficiency * Active or prior documented autoimmune or inflammatory disorders (including inflammatory bowel disease \[e.g., colitis or Crohn's disease\], diverticulitis \[with the exception of diverticulosis\], systemic lupus erythematosus, Sarcoidosis syndrome, or Wegener syndrome. The following are exceptions to this criterion: * Patients with vitiligo or alopecia * Patients with hypothyroidism (e.g., following Hashimoto syndrome)stable on hormone replacement * Any chronic skin condition that does not require systemic therapy * Patients without active disease in the last 5 years may be included but only after consultation with the study physician. * Active infection including tuberculosis (clinical evaluation that includes clinical history, physical examination and radiographic findings, and TB testing in line with local practice), hepatitis B (known positive HBV surface antigen (HBsAg) result), hepatitis C, or human immuno-deficiency virus (positive HIV 1/2 antibodies). Patients with a past or resolved HBV infection (defined as the presence of hepatitis B core antibody \[anti-HBc\] and absence of HBsAg) are eligible. Patients positive for hepatitis C (HCV) antibody are eligible only if polymerase chain reaction is negative for HCV RNA. * Medical or psychological condition which in the opinion of the investigator would not permit the patient to complete the study or sign meaningful informed consent.

Primary outcome measure(s)

  • Recurrence-free survival — 3 years
    RFS is defined as time from randomization until date of any recurrence (local or distant) or date of death due to any cause.

Trial sites (60)

FacilityCityRegionStatus
Antwerp University Hospital Antwerp Belgium Recruiting
Clinique Universitaire Saint-Luc Brussels Belgium Recruiting
GHDC Charleroi Belgium Recruiting
CHU Helora Mons Belgium Recruiting
CHU UCL Namur Namur Belgium Recruiting
AZ Damiaan Ostend Belgium Recruiting
Juravinski Cancer Center Hamilton Canada Recruiting
BCCA Kelowna Kelowna Canada Recruiting
Kingston Health Sciences Centre Kingston Canada Recruiting
London Regional Cancer Centre London Canada Recruiting
Centre Hospitalier de Universite de Montreal Montreal Canada Recruiting
Jewish General Hospital Montreal Canada Recruiting
Maisonneuve-Rosemont Hospital Montreal Canada Recruiting
Allan Blair Cancer Centre Regina Canada Recruiting
Saint John Regional Center Saint John Canada Recruiting
Saskatoon Cancer Centre Saskatoon Canada Recruiting
Centre hospitalier universitaire de Sherbrooke Sherbrooke Canada Recruiting
Princess Margaret Cancer Centre Toronto Canada Recruiting
Sunnybrook Health Science Centre Toronto Canada Recruiting
BC Cancer Vancouver Vancouver Canada Recruiting
BCCA Victoria Victoria Canada Recruiting
Fakultní nemocnice Hradec Králové Hradec Králové Czechia Recruiting
FN Bulovka Prague Czechia Recruiting
FN Motol Prague Czechia Recruiting
Všeobecná fakultní nemocnice v Praze Prague Czechia Recruiting
CHU Jean Minjoz Besançon France Recruiting
Institut Bergonie Bordeaux France Recruiting
Institut Leon Berard Lyon France Recruiting
Institut Paoli Calmattes-Marseille Marseille France Recruiting
Institut du cancer de Montpellier Montpellier France Recruiting
Centre Antoine Lacassagne Nice France Recruiting
ICO Saint Herblain Saint-Herblain France Recruiting
Clinique Sainte-Anna Strasbourg France Recruiting
Institut Universitaire de Cancer de Toulouse Toulouse France Recruiting
Institute Gustave Roussy Villejuif France Recruiting
Evangelisches Waldkrankenhaus Spandau Berlin Berlin Germany Recruiting
Klinikum Lippe Detmold Germany Recruiting
Universitätsklinikum Hamburg-Eppendorf Hamburg Germany Recruiting
Universitätsklinikum Heidelberg Heidelberg Germany Recruiting
Klinikum Kempten Kempten Germany Recruiting

+ 20 more sites — see the full list on the official registry below.

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05255653 on ClinicalTrials.gov ↗ ← All trials in Germany