Study of the Intracerebral Electrophysiological Signature in the Epileptic Patient
Condition(s) studied
Investigational drug(s) / intervention(s)
Cognitive tasks in the form of questionnaires: During their hospitalization for SEEG, patients will perform cognitive tasks to assess memory, vision, attention, language, and decision-making.
Study summary
As part of the clinical management of certain severe, drug-resistant forms of epilepsy, it is necessary to implant electrodes in the brain to identify the epileptic network prior to potential neurosurgical resection of the source zones. This standardized procedure, known as Stereo-Electroencephalography (SEEG), was developed in France in the 1960s. The electrodes remain implanted for several days-typically two weeks-while awaiting spontaneous epileptic seizures. During this period, the patient remains hospitalized, and their electroencephalographic activity is recorded around the clock.
Patients can be asked to perform cognitive tasks (such as tasks involving memory, attention, vision, language, and decision-making) while awake or asleep; the results can then be correlated with the intracerebral electroencephalographic activity recorded simultaneously as part of their clinical care. This approach makes it possible to capture the electrophysiological signatures of specific cognitive processes, thereby enabling researchers to: 1) create a brain map of electrophysiological signatures, 2) improve standard models of cognitive function, and 3) study the dysfunction of these processes in epilepsy.
Eligibility
Primary outcome measure(s)
- Construction of a database of electrophysiological signatures of various cognitive functions — 3 weeks after the inclusion
Correlation of performance on a task involving a neurocognitive process with characteristics of brain activity recorded during the task (electrophysiological signature) using intracranial stereo-electroencephalography (SEEG) electrodes.
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Electrophysiologie cérébrale, épilepsie, sommeil, Hôpital Pierre Paul Riquet | Toulouse | Oui |
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07796984 on ClinicalTrials.gov ↗ ← All trials in France