Host-microbiota Interactions in Auto-inflammatory Diseases
Condition(s) studied
Study summary
Autoinflammatory diseases (AID) are genetic diseases responsible for excessive activation of innate immunity leading to blood inflammation and systemic symptoms. Most patients display digestive involvements that may resemble inflammatory bowel disease. Several studies have found dysbiosis in some AID. Gut microbiota can communicate with the host via gut-derived metabolites (Fatty acids, tryptophan, bile acids) that may have either pro-inflammatory or anti-inflammatory effects. Some metabolites can also activate the Aryl hydrocarbon receptor (AhR) pathway, which enhances gut barrier. Gut barrier dysfunction has already been associated with AID. Therfore, dysbiosis could promote digestive and inflammatory involvements in genetically predisposed patients via perturbations of gut-derived metabolites.
Eligibility
Primary outcome measure(s)
- Stool and blood Gut-derived metabolites in patients with AID — 3 months
Quantification of gut-derived metabolites in stools using mass spectrometry - Stool and blood Gut-derived metabolites in patients with AID — 3 months
Qualitative evaluation of gut-derived metabolites in stools
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Internal medicine, Tenon Hospital (APHP) | Paris | France | Recruiting |
More Assistance Publique - Hôpitaux de Paris trials in France
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07718555 on ClinicalTrials.gov ↗ ← All trials in France