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Clinical Trials in France / NCT07682246
Starting soon Observational

EFFECT OF PLATELET CONCENTRATE TRANSFUSION ON MICROCIRCULATORY ENDOTHELIAL FUNCTION IN INTENSIVE CARE UNIT

NCT07682246 · tracked via the Priya Life Science France tracker
Sponsor
Assistance Publique - Hôpitaux de Paris
Phase
Observational
Started
2026-07
Last updated
2026-07-02

Condition(s) studied

ThrombocytopeniaProphylactic Platelet TransfusionPlatelet TransfusionEndothelial Function

Study summary

This study aims to investigate the impact of platelet concentrate (PC) transfusions on endothelial function and the systemic inflammatory response in thrombopenic patients admitted to intensive care who require prophylactic platelet transfusions.

Endothelial function will be measured using a laser Doppler device coupled with an acetylcholine iontophoresis system that is applied to the skin.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Adult patient ≥ 18 years of age * Admitted to intensive care * Requires prophylactic platelet transfusion for thrombocytopenia * Enrolled in a social security program * No objection to participating in the study Exclusion Criteria: * Recent platelet or red blood cell transfusion (\< 24 hours) * Need for urgent red blood cell transfusion due to active bleeding * Patient under guardianship or conservatorship * Significant peripheral edema

Primary outcome measure(s)

  • Assessing the effects of platelet transfusion on endothelial function in the microcirculation. Endothelial function will be measured using a Doppler laser coupled with an acetylcholine iontophoresis system applied to the skin. — before transfusion, right after transfusion and 1 hour after transfusion
    The area under the microcirculatory blood flow curve is measured over 10 minutes using a cutaneous laser Doppler sensor coupled with iontophoresis (Périmed, France). The data is analysed using computer software connected to the Doppler device.

Trial sites (1)

FacilityCityRegionStatus
Medical Intensive Care Unit, Saint-Antoine Hospital, AP-HP, Paris, France Paris France

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Other trials for the same condition

Contribution of Anti-platelet Antibodies Identified With MAIPA Assay in the Demonstration of the Auto-immune Character of a Thrombocytopenia at Diagnosis Recruiting
Eltrombopag for the Treatment of Thrombocytopenia Due to Low- and Intermediate Risk Myelodysplastic Syndromes Active, not recruiting
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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07682246 on ClinicalTrials.gov ↗ ← All trials in France