Evaluation of the Effect of Kefir Consumption

Condition(s) studied

Investigational drug(s) / intervention(s)

Consumption of a control beverage, non-fermented carbonated drink: Consumption of a control beverage, non-fermented carbonated drink and measurement of the concentrations of metabolites such as BCAAs (valine, leucine, and isoleucine) in the biofluids (urine and saliva) of subjects, before and after regular consumption of fruit kefir.

Consumption of fruit kefir: Consumption of fruit kefir and measurement of the concentrations of metabolites such as BCAAs (valine, leucine, and isoleucine) in the biofluids (urine and saliva) of subjects, before and after regular consumption of fruit kefir.

Consumption of micro-filtered fruit kefir: Consumption of micro-filtered fruit kefir and measurement of the concentrations of metabolites such as BCAAs (valine, leucine, and isoleucine) in the biofluids (urine and saliva) of subjects, before and after regular consumption of fruit kefir.

Study summary

Many societies traditionally use fermentation as a means of producing beverages, whose microbial transformation is spontaneously triggered or facilitated by the addition of a catalyst (yeasts, bacteria). Kefir is a traditional beverage belonging to the latter category.

It is a probiotic that is supposed to modify the intestinal microbiota and the metabolites produced.

Links between kefir and metabolic syndromes (insulin resistance, etc.) have also been described in animal models. Very few clinical studies have evaluated the effects of kefir in humans.

A 'positive feeling' has also been described by people who consume kefir. Kefir could therefore have an effect on people's well-being.

Eligibility

Primary outcome measure(s)

• Evaluate the effects of fruit kefir — 3 years
  Evaluate the effects of fruit kefir on the release of amino acids such as BCAAs and more generally of metabolites in human biofluids (urine and saliva). The measurement of the concentrations of metabolites such as BCAAs (valine, leucine, and isoleucine) carried out in the biofluids (urine and saliva) of subjects, before and after regular consumption of fruit kefir using IDIR enzymatic dosage kit for BCAAs in a urine sample (SkillCell, France) according to the supplier's instructions. The concentrations are expressed in µM.

Trial sites (1)

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