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Clinical Trials in France / NCT07427537
Recruiting Not applicable

Exploration of Circulating microRNAs as Biomarkers of Chemo-induced Peripheral Neuropathy: a Study in Cancer Patients

NCT07427537 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Clermont-Ferrand
Phase
Not applicable
Started
2026-01-29
Last updated
2026-02-23

Condition(s) studied

Cancer, LungColon NeoplasmNeuropathy;Peripheral

Investigational drug(s) / intervention(s)

Assessment of blood concentrations of microRNAsChemotherapy-induced peripheral neuropathy (CIPN) - gradePain assessementAssessment of blood concentrations of neurofilament light chainNeuropathic pain assessmentChemotherapy-induced peripheral neuropathy (CIPN) - severity

Assessment of blood concentrations of microRNAs: day 1, day 43, and day 155.

Chemotherapy-induced peripheral neuropathy (CIPN) - grade: day 1, day 43, and day 155.

Pain assessement: day 1, day 43, and day 155.

Assessment of blood concentrations of neurofilament light chain: day 1, day 43, and day 155.

Neuropathic pain assessment: day 1, day 43, and day 155.

Chemotherapy-induced peripheral neuropathy (CIPN) - severity: day 1, day 43, and day 155.

Study summary

This study aims to find out whether certain molecules in the blood, called microRNAs, are linked to how often and how severely people develop nerve damage from chemotherapy. The investigators will look at patients receiving cancer drugs known to affect the nerves, such as paclitaxel (used for lung cancer) and oxaliplatin (used for colorectal cancer).

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Patient treated for colorectal cancer and scheduled to receive oxaliplatin-based adjuvant chemotherapy for at least 6 cycles, or * Patient treated for lung cancer and scheduled to receive paclitaxel-based chemotherapy for at least 4 cycles. Exclusion Criteria: * Neurodegenerative disease (e.g., Parkinson's, Alzheimer's, etc.), * History of stroke, * Pre-existing neuropathy (QLQ-CIPN20 sensory score ≥ 15/100), * Pain (NRS ≥ 4/10), * Pregnant or breastfeeding women, * Patients under guardianship, curatorship, deprived of liberty, or under legal protection

Primary outcome measure(s)

  • Blood concentrations of microRNAs and severity score of sensory chemotherapy-induced peripheral neuropathy — day 1, day 43, and day 155
    Concentrations of microRNAs will be assessed in plasma, and severity score of sensory chemotherapy-induced peripheral neuropathy will be assessed using the QLQ-CIPN20 questionnaire.

Trial sites (1)

FacilityCityRegionStatus
CHU Clermont-Ferrand Clermont-Ferrand France Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07427537 on ClinicalTrials.gov ↗ ← All trials in France