Clinical Trials in France / NCT07427498
Recruiting
Observational
The Role of Priors in Hallucinatory Perception in Parkinson's Disease
NCT07427498 · tracked via the Priya Life Science France tracker
Condition(s) studied
PARKINSON DISEASE (Disorder)
Study summary
The goal of this observational study is to better understand the mechanisms of hallucinations in patients with Parkinson's disease. The main question it aims to answer is:
Do prior expectations increase the rate of false perceptions during a visual stimulus detection task more in Parkinson's disease patients with visual hallucinations compared to those without?
Participants will undertake a computer task involving face detection and a battery of neuropsychological tests.
Eligibility
Inclusion Criteria:
* Adults diagnosed with Parkinson's disease (with or without visual hallucinations) or healthy volunteers.
* Age 18 - 85 years.
* Consent to participate.
Exclusion Criteria:
* Currently participating in another clinical or therapeutic trial involving the testing of a drug treatment.
* Inability to perform cognitive tests due to:
Non-psychiatric (somatic) conditions likely to affect cognitive abilities. Peripheral sensory or motor deficits. Acute clinical conditions (e.g., agitation, impaired consciousness).
* Diagnosis of dementia.
* Individuals covered by Articles L1121-5 to L1121-8 of the French Public Health Code (Code de la Santé Publique), including:
Pregnant women, women in labor, or breastfeeding mothers. Individuals deprived of liberty by judicial or administrative decision. Individuals receiving psychiatric care under Articles L. 3212-1 and L. 3213-1 (excluding those covered by Article L. 1121-8).
Individuals admitted to a healthcare or social institution for purposes other than research.
Minors or adults under legal guardianship or unable to express consent.
\- Individuals with a hierarchical relationship to any professional involved in the study.
Only for healthy volunteers:
\- Personal history of diagnosed neurological disorders.
Post-Inclusion Exclusion:
\- Participants included in the study but found to have a MoCA score below 24 will be excluded from the study.
Primary outcome measure(s)
- Effect of Prior Expectations on False Alarm Rates in Parkinson's Disease Patients With and Without Visual Hallucinations — Baseline
The primary outcome measures the false alarm rate during a visual stimulus detection task, specifically the percentage of trials in which participants report perceiving a stimulus when none was presented. The study will assess whether prior expectations (cues indicating the likelihood of a stimulus) increase false alarm rates more in Parkinson's disease patients with visual hallucinations compared to those without. The primary statistical analysis will test for an interaction effect (p \< 0.05) between cue (prior expectation), stimulus presence, and group (patients with vs. without hallucinations) using a generalized linear mixed model.
Trial sites (2)
| Facility | City | Region | Status |
|---|---|---|---|
| CHU Grenoble Alpes | Grenoble | France | Recruiting |
| Grenoble University Hospitals | La Tronche | France | Recruiting |
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Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07427498 on ClinicalTrials.gov ↗ ← All trials in France