Assessment of Airway Opening Pressure in Invasively Ventilated Children

Condition(s) studied

Investigational drug(s) / intervention(s)

Measurement of airway opening pressure: Measurement of airway opening pressure in invasively ventilated pediatric patients with 2 methods, "fixed flow method" and "pediatric slow flow method". The two methods will be separated by a washout period. The order of the airway opening pressure detection methods will be random.

Study summary

Acute respiratory distress syndrome (ARDS) in children is associated with significant morbidity and mortality. Current studies seek to individualize the management of children by defining several phenotypes, based until now mainly on clinical presentation. A better understanding of the respiratory mechanics of each patient could allow the individualization of other phenotypes and adapt their management with individualized ventilation. The method for detecting airway opening pressure (AOP) in children has not yet been validated and the reference methods in adults are difficult to apply in children due to their physiological particularities.

The main objective of the study is to evaluate the feasibility of two methods for measuring airway opening pressure in invasively ventilated pediatric patients.

Eligibility

Primary outcome measure(s)

• Feasibility of the two methods of measuring airway opening pressure — 5 years
  The method will be considered feasible if at least one maneuver out of three allows a measurement of the airway opening pressure to be obtained.

Trial sites (1)

More Assistance Publique - Hôpitaux de Paris trials in France