Using a Fixed Dosage of Follitropin Delta for Ovarian Stimulation for Intrauterine Insemination: Rekovelle for Intrauterine Successful Experience (RISE)
Condition(s) studied
Investigational drug(s) / intervention(s)
REKOVELLE (Follitropin Delta): Each patient will start the ovarian stimulation with a fixed dose of 3,66 mcg of Rekovelle ® on day 4 of the natural cycle (Stimulation day 1-S1). The stimulation period will last a maximum of 13 days. Patients will be regularly evaluated to monitor the response to stimulation with ultrasound scan and blood sampling
Study summary
The aim of this study is to evaluate the use of a fixed dose of 3.66 mcg of follitropin delta (Rekovelle) on ovarian response during ovarian stimulation for intrauterine insemination (IUI). The assumption is that this fixed dose will be effective while minimizing the risk of multiple pregnancies. A recent study demonstrated the efficacy of follitropin delta for ovarian stimulation in IUI, and it has been approved in France for controlled ovarian stimulation in assisted reproductive techniques such as in vitro fertilization (IVF) and IVF with intracytoplasmic sperm injection (ICSI). With an adapted dose of Rekovelle for patients with regular menstrual cycles, ovarian stimulation is optimized from the first attempt, promoting the development of two follicles to improve pregnancy chances while reducing the risk of multiple pregnancies. This approach aims to achieve pregnancy faster and provide a more comfortable treatment experience.
Eligibility
Primary outcome measure(s)
- Percentage of cycles with two mature follicles (total of two ovaries) at the stage of triggering ovulation — up to 9 months
Percentage of cycles with two mature follicles (total of two ovaries) at the stage of triggering ovulation (follicles diameter ≥14 mm) and no follicles between 10 et 13 mm.
Trial sites (5)
| Facility | City | Region | Status |
|---|---|---|---|
| Cabinet Dr Elodie Descat-Polyclinique Jean Villar | Bruges | France | Recruiting |
| Chi Creteil | Créteil | France | Recruiting |
| Cabinet Dr Géraldine PORCU-Institut de Médecine de la Reproduction | Marseille | France | Recruiting |
| Cabinet Dr Nicolas Chevalier-Centre AMP Saint Roch | Montpellier | France | Recruiting |
| Cabinet Dr Nathalie Massin- Hôpital Américain De Paris | Neuilly-sur-Seine | France | Suspended |
More Centre Hospitalier Intercommunal Creteil trials in France
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07153367 on ClinicalTrials.gov ↗ ← All trials in France