Epidemiology of Gonococcal Arthritis (EpGAr)

NCT06897943 · tracked via the Priya Life Science France tracker

Sponsor

University Hospital, Brest

Phase

Observational

Started

2024-12-01

Last updated

2025-03-27

Condition(s) studied

Gonococcal (GC) InfectionArthritis, Infectious

Study summary

The aim of this retrospective observational study was to describe the epidemiology of Neisseria gonorrhoeae septic arthritis over the last 10 years at Brest and Rennes university hospitals. The main question is whether there are any risk factors based on the epidemiological and clinical data on these cases. The second objective is to characterize the gonococcal strains isolated in order to determine whether there is a common clone, a virulence factor or specific resistance genes.

Eligibility

Sex

ALL

Min age

—

Max age

—

Healthy volunteers

Inclusion Criteria: * Patients with a Neisseria gonorrhoeae-positive joint sample (from an enrichment vial or a native sample) between 2014 and 2024. Exclusion Criteria: * Patients with Neisseria gonorrhoeae-negative joint sample (from enrichment vial or native sample). * Patients who have expressed opposition to inclusion in the study. * Patients under legal protection (guardianship, curatorship, etc.).

Primary outcome measure(s)

Age — 10 years
years
Date of sampling — 10 years
DD/MM/YYYY
Type of sample — 10 years
joint fluid or joint fluid on blood culture bottle
Rate of white blood cells — 10 years
quantification of white blood cells /mm3
Sexually transmitted infection — 10 years
associated or not, if associated, name of STI and localization
Men who have sex with men — 10 years
yes or no
HIV pre-exposure prophylaxis (PreP) — 10 years
yes or no
Comorbidities — 10 years
any history mentioned in the medical file, such as fracture, illness, treatment, chronic alcoholism, cancer, diabetes, etc.
Imaging — 10 years
medical conclusion of the ultrasound or radiology performed
Blood cultures (peripheral blood) — 10 years
positive or negative
Time to diagnosis — 10 years
in days (between onset of symptoms and antibiotics)
Treatments implemented — 10 years
name of the probabilistic treatment (antibiotic) and after identification or antibiogram
Antibiotic sensitivity profile — 10 years
Susceptibility or resistance according to SIR methodology and, if achieved: minimum inhibitory concentrations of antibiotics tested on the strain in mg/L
Surgery — 10 years
yes or not
Evolution — 10 years
recovery or relapse
Rate of neutrophils — 10 years
proportion of neutrophils in %.
Rate of CRP (C-reactive protein) — 10 years
in mg/L

Trial sites (2)

Facility	City	Region	Status
Rennes University Hospital	Rennes	Brittany Region	Recruiting
CHU de BREST	Brest	France	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06897943 on ClinicalTrials.gov ↗ ← All trials in France