Contribution of New Pancreatic MRI Sequences for the Evaluation of Tumor Response in Pancreatic Adenocarcinomas

Condition(s) studied

Investigational drug(s) / intervention(s)

Magnetic resonance elastography (MRE).: Magnetic resonance elastography (MRE) is an imaging technique that measures tissue stiffness by assessing the deformation waves produced under external pressure

High-resolution diffusion sequence in MRI: High-resolution diffusion sequence in MRI is an imaging technique that uses the movement of water molecules within tissues to generate detailed images.

Study summary

Pancreatic adenocarcinoma is the most pessimistic digestive cancer in terms of prognosis. Tumor response assessment is crucial, and the recent development of new magnetic resonance imaging sequences, such as high resolution applied to diffusion sequences (Harder et al., 2022) or magnetic resonance elastography (MRE) (Steinkohl et al., 2021), could help address this issue.

Eligibility

Primary outcome measure(s)

• Absolute elasticity value of the tumor (kPa) before treatment. — Baseline (J0) before treatment
  The absolute elasticity value of the tumor corresponds to the average elasticity value measured within the region of interest, which will be outlined according to the tumor's boundaries.
• Absolute elasticity value of the tumor (kPa) after chemotherapy. — 3 months, after chimiotherapy
  The absolute elasticity value of the tumor corresponds to the average elasticity value measured within the region of interest, which will be outlined according to the tumor's boundaries.

Trial sites (1)

More Central Hospital, Nancy, France trials in France