The goal of this innovative project is to evaluate the correspondence between several imaging modalities for characterizing the elasticity of healthy and pathological renal tissue which could help improve the realism of 3D prints used by urological surgeons and allow the identification of new, complementary imaging biomarkers. The main objective is to develop a predictive model of the biomechanical properties of normal and pathological kidney tissue, as assessed by the reference method (Magnetic Resonance (MR)-elastography).
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Adult patients (≥ 18 years of age)
* Scheduled for surgical management with nephrectomy for kidney tumor in the urology department of Bordeaux University Hospital
* CT scan available or scheduled for surgery
* Consent expressed for integration of the UroCCR database
* Expressed consent for participation in the Rein 3D Print Mechanics study
* Patients affiliated or benefiting from social security system
Exclusion Criteria:
* \- Pregnant or breast-feeding women
* Contraindication to MRI (Magnetic Resonance Imaging)
* Contraindication to injection of gadoline contrast agents
* Biopsy performed within 15 days prior to MRI, CT and ultrasound scans (risk of artifactual alteration, via iatrogenic hemorrhagic changes, of the biomechanical properties of the renal tumor and parenchyma).
* Presence of thoracolumbar arthrodesis material
* Obese patient (body mass index ≥ 30 kg/m²)
* Cystic renal tumors with solid component (corresponding to either parietal thickening or tumor bud) \< 2 cm
* Necrotic renal tumors with solid component (corresponding to either parietal thickening or tumor bud) \< 2 cm
* Ascites
* Person under legal protection
* Difficulty understanding and expressing in French
Primary outcome measure(s)
Measurement of the root mean square error (RMSE) — Between Day 0 and Month 4 The aim is to successfully predict μMRE from dCT-, dCT40s, dCT90s, dCT10min (naming μCT the scan model prediction) with the lowest possible error.
Trial sites (1)
Facility
City
Region
Status
CHU de Bordeaux
Bordeaux
France
Recruiting
More University Hospital, Bordeaux trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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