Mapping Epileptic Networks Using Multimodal Imaging

NCT06202976 · tracked via the Priya Life Science France tracker

Sponsor

Imagine Institute

Phase

Observational

Started

2017-09-14

Last updated

2025-04-17

Condition(s) studied

Epilepsy in Children

Investigational drug(s) / intervention(s)

Secondary data collection

Secondary data collection: clinical data

Study summary

Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations.

To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI).

It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery.

The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.

Eligibility

Sex

ALL

Min age

—

Max age

18 Years

Healthy volunteers

Inclusion Criteria: * Be under 18 years of age on the day of inclusion. * Present with one of the following forms of epilepsy: * refractory focal lesional epilepsy * rare non-lesional epilepsy * Present abnormalities (spikes) on the intercritical EEG * Have been selected by the "Epilepsy" multidisciplinary staff. * In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup. * Be affiliated to a health insurance scheme. Exclusion Criteria: * Requiring general anesthesia for MRI * Require sedation specifically for research * Have generalized epilepsy * Be deprived of liberty or under guardianship.

Primary outcome measure(s)

Determine whether, in children with lesional focal epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG can accurately identify the epileptogenic zone to be defined by SEEG, today's gold standard. — 15 years

Trial sites (1)

Facility	City	Region	Status
Necker - Enfants Malades Hospital	Paris	France	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06202976 on ClinicalTrials.gov ↗ ← All trials in France