Role of MDSCs and Cancer Stem Cells and Their Cross Talks in NSCLC

Condition(s) studied

Investigational drug(s) / intervention(s)

Tumor samples: Tumor samples will be collected by the pathologist at the reception of the tumor removed during surgery

Study summary

Immunotherapy have revolutionized the field of oncology, but response rates are low and all patients relapse, due to cellular and soluble immunosuppressive mechanisms. MDSC are one of the most important immunosuppressive cells, that also harbour non immunologic functions, favouring cancer invasion. These non immunologic functions of MDSC in lung cancer will be better characterized. Indeed, cellular mechanisms will be analysed by in vitro studies, assessing the effect of immunosuppressive cells, provided by fresh tumor samples, on phenotype and functions of lung cancer cell lines. The aim of this study is to better characterize immunosuppressive landscape of NSCLC and mechanisms involved in their protumor functions.

Eligibility

Primary outcome measure(s)

• Comparative analysis of the modifications of phenotype and functions of lung cancer cell lines when exposed to MDSC extracted from patient tumor tissue — At the time of surgery only, when fresh tumor is resected
  Functional in vitro studies of the effect of MDSC extracted from resected NSCLC prospectively collected on phenotype and function of lung cancer cell lines

Trial sites (1)

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