Early Detection of Alzheimer's Disease and Affective Disorders by Automated Voice and Speech Analysis (PLATA)

NCT05943834 · tracked via the Priya Life Science France tracker

Sponsor

Centre Hospitalier Universitaire de Nice

Phase

Observational

Started

2023-07-13

Last updated

2026-03-19

Condition(s) studied

Neurocognitive Disorders

Investigational drug(s) / intervention(s)

Series of cognitive tasks during a semi-automated call

Series of cognitive tasks during a semi-automated call: Tasks: * Verbal learning recall (immediate) or Story Recall task (immediate) * Narrative Storytelling /free speech * Verbal fluency task * Verbal learning recall (delayed) or Story Recall task (delayed)

Study summary

PLATA aims to develop an algorithm to identify vocal biomarkers of Alzheimer's dementia.

Using data collected as part of routine care, speech patterns will be compared to known biomarkers of Alzheimer's disease, such as amyloid 1-42 and p-Tau in CSF (cerebrospinal fluid).

If biomarkers of speech can be identified in Alzheimer's disease, it is possible that patients and research participants will no longer need to undergo need to undergo the intensive and invasive baseline biomarker methods currently used, such as lumbar punctures and PET scans.

Eligibility

Sex

ALL

Min age

50 Years

Max age

100 Years

Healthy volunteers

Inclusion Criteria: * Age ≥ 50 years * Diagnosis relevant biomarker and neuropsychological data already available * Cognitively healthy to very mild dementia (CDR score max. 0.5) * Sufficient knowledge of the study language to understand study information, non opposition form,and questionnaires * Expression of non opposition Exclusion Criteria: * Hearing problems * Patient protected by law, under guardianship or curator ship, or not able to participate in a clinical study according to the article L.1121-16 of the French Public Health Code

Primary outcome measure(s)

Build and validate speech-based machine learning models for relevant Phenotype detection through access to phenotyped patients from reference memory center. — 20 minutes
Speech biomarker algorithm(s)

Trial sites (1)

Facility	City	Region	Status
CHU de Nice	Nice	France	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05943834 on ClinicalTrials.gov ↗ ← All trials in France