Effect of Transcranial Near InfraRed Light on Cerebral Function in Young and Healthy Older Subjects: a FMRI Study (TIROC)

Condition(s) studied

Investigational drug(s) / intervention(s)

ACTIVE Transcranial photobiomodulation (tPBM): fMRI records before and after ACTIVE Transcranial photobiomodulation (tPBM)

SHAM Transcranial photobiomodulation (tPBM): fMRI records before and after SHAM Transcranial photobiomodulation (tPBM)

Study summary

Numerous studies have shown that the extra-cranial application of near infrared light (λ=600-1000nm) (also called transcranial photobiomodulation or tPBM), has a positive impact on brain function in both humans and experimental animal models and a neuroprotective effect in animal models. Several of these studies have reported that tPBM could impart more beneficial effects in aged or diseased brains. The primary objective of this study is to use fMRI to compare the cerebral activations in response to a finger tapping motor task, before and after 24min of tPBM versus sham stimulation, in old and young healthy human subjects.

The hypothesis of the investigators is that tPBM improves brain function in participants who will be treated using the active device in comparison with those treated with the sham device and that this effect should will be more pronounced in the older subjects.

Eligibility

Primary outcome measure(s)

• Cerebral activations in response to a Finger Tapping motor task. — 24 minutes
  Cerebral activation measured by fMRI (BOLD signal change) in response to a finger tapping motor tap (contrasted against a resting baseline), before and after tPBM/Sham stimulation

Trial sites (1)

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