Reality-monitoring & Stress

Condition(s) studied

Investigational drug(s) / intervention(s)

Acute Maastricht Stress Test (MAST), active condition.: The MAST is a standardized stress protocol combining a 5 min preparation phase and 10 min acute stress phase. The last phase is composed by an alternation of physical and psychosocial stressors. In the active condition, participants have to switch between immersion of the hand into cold water and complex mental arithmetic operations.

Acute Maastricht Stress Test (MAST), placebo condition: The MAST is a standardized stress protocol combining a 5 min preparation phase and 10 min acute stress phase. The last phase is composed by an alternation of physical and psychosocial stressors. In the placebo condition, participants have to switch between immersion of the hand into tempered water and simple mental arithmetic counts.

Study summary

Reality-monitoring is a crucial cognitive process in daily life to remember the source of an information. Deficits of reality-monitoring have been shown into the continuum of schizophrenia, suggesting a preexisting alteration in population at-risk for psychosis that will be exacerbated during psychotic transition. It is admitted that stress plays a crucial role in the psychotic transition and can alter cognitive performances. However, less is known about the effects of stress on reality-monitoring, even though this process appears to be central in psychotic disorders.

The aim of this project is to investigate the effect of stress on reality-monitoring, both on behavioral and neurophysiological aspects

Eligibility

Primary outcome measure(s)

• Reality-monitoring performances — within 1 hour after the stress procedure
  scores obtained at the reality-monitoring task (accuracy, range 0-100%)

Trial sites (1)

More Hôpital le Vinatier trials in France

Other trials for the same condition