Search for BIO Diagnostic and Prognostic Markers in Adult VAScularitis

Condition(s) studied

Investigational drug(s) / intervention(s)

Sampling: 4 blood sampling per patient and an additional one in case of relapse

Study summary

To date, there are no reliable diagnostic blood markers of adult vasculitis. To date, the diagnosis of vasculitis is based on invasive procedure, biopsy of affected tissues potentially at risk of complication . In addition, there are no reliable biomarkers to predict the evolution of vasculitis (relapse, refractory form ...) necessary for the management of patients (type of treatment, duration ..)

Prospective study, monocentric (CHU de Tours), non-interventional, aimed at finding diagnostic and prognostic biomarkers (both metabolomic and immunologic) in adult vasculitis patients.

Eligibility

Primary outcome measure(s)

• cytokine/chemokine/metabolite concentrations — Baseline
  Analysis by méthod Luminex
• cytokine/chemokine/metabolite concentrations — Month 1
  Analysis by méthod Luminex
• cytokine/chemokine/metabolite concentrations — Month 3
  Analysis by méthod Luminex
• cytokine/chemokine/metabolite concentrations — Month 12
  Analysis by méthod Luminex
• cytokine/chemokine/metabolite concentrations — date of relapse assessed up to 12 months
  Analysis by méthod Luminex
• percentage of different non-conventional T cell populations — Baseline
  study by flow cytometry
• percentage of different non-conventional T cell populations — Month 1
  study by flow cytometry
• percentage of different non-conventional T cell populations — Month 3
  study by flow cytometry
• percentage of different non-conventional T cell populations — Month 12
  study by flow cytometry
• percentage of different non-conventional T cell populations — date of relapse assessed up to 12 months
  study by flow cytometry

Trial sites (1)

More University Hospital, Tours trials in France

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