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Clinical Trials in France / NCT05258396
Recruiting Not applicable

Exploring Cortical Remyelination in Children With Multiple Sclerosis

NCT05258396 · tracked via the Priya Life Science France tracker
Sponsor
Assistance Publique - Hôpitaux de Paris
Phase
Not applicable
Started
2022-08-11
Last updated
2026-03-06

Condition(s) studied

Children With Multiple Sclerosis

Investigational drug(s) / intervention(s)

MRI without injection of contrast product

MRI without injection of contrast product: MRI without injection of contrast product

Study summary

Multiple sclerosis (MS) in children, a rare disease, follows a relapsing remitting course with a shorter interval between the first 2 clinical events and higher annualized relapse rate as compared with MS in adults. Residual deficits following clinical events are less frequent. The vast majority of children and adolescents with MS are thought to have a greater potential for myelin repair than adults. However convincing data in the literature to support this hypothesis are lacking, because until now no imaging technique has been validated to measure remyelination in vivo.

Eligibility

Sex
ALL
Min age
12 Years
Max age
18 Years
Healthy volunteers
Accepted
Inclusion Criteria for patients : * age between 12 years old and 18 years old * RR-MS defined by 2017 McDonald criteria * no relapse the last 4 weeks * no methylprednisolone or prednisolone the last 4 weeks. * affiliated to the social security system * signature of the consent by the 2 holders of parental authority Inclusion Criteria for Volunteers: * age between 12 years old and 18 years old * absence of any neurological * signature of the consent by the 2 holders of parental authority Exclusion Criteria for both groups: * Parental rejection * Contre-indication of brain MRI: pace maker, tatoo of the face, claustrophobia…. * Pregnancy, copper intrauterine device

Primary outcome measure(s)

  • MTR-based individual indices — 1 day
    To investigate the association between MTR-based individual indices of cortical myelin repair in children with MS and one cognitive score (Symbol Digital Modalities Test (SDMT)) at baseline

Trial sites (3)

FacilityCityRegionStatus
Service de Neurologie Pédiatrique, Hôpital du Kremlin Bicêtre Le Kremlin-Bicêtre France Recruiting
CIC Neurosciences - Pitié Salpêtrière Paris France Recruiting
Service de Neurologie, GH Pitié Salpêtrière Paris France Not Yet Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05258396 on ClinicalTrials.gov ↗ ← All trials in France