Birdshot Chorioretinopathy : Prospective Follow-up and Immunogenetic Studies(CO-BIRD)

Condition(s) studied

Investigational drug(s) / intervention(s)

Observational study: The goal of the study is purely observational. Treatment decisions will be made by physicians according to the grading of the intraocular inflammation related to birdshot chorioretinopathy and to their consequences on visual function. These treatment decisions will be independent from the observational study.

Study summary

The purpose of this study is twofold:

1. To analyze the clinical features of a cohort of patients with birdshot chorioretinopathy (BCR), an inflammatory bilateral ocular disease, affecting the choroid and the retina.

Various imaging techniques will be used to assess the effect of the disease on the retina and the choroid.

A standardized assessment of the visual function will be performed with visual acuity, visual field and color vision testing. The quality of life of the patients will be evaluated with the VFQ-25 questionnaire.

These analyses will help delineating different forms of the disease among its heterogeneous presentations.
2. To identify predisposing factors for the disease. The condition is unique from the immunogenetic standpoint by its association with the HLA-A29 allele, which is the strongest link between an HLA class I antigen and a disease. To date, however, the mechanisms leading to birdshot chorioretinopathy remain unknown. GWAS (Genome Wide association Study) based on DNA of the cohort patients will be performed with the aim to identify other susceptibility genes associated with BCR.

Eligibility

Primary outcome measure(s)

• Best Corrected Visual Acuity (BCVA) — Through study completion, an average of 1 year
  Standard decimal clarity for distance visual acuity. It is expressed from 0 which is minimum \& worse value, corresponding to no light perception; to 1.0 (20/20) which is maximum \& best value
• Visual field testing — Through study completion, an average of 1 year
  Humphrey 30-2 automated threshold perimetry with foveal sensitivity. It is expressed in Mean Deviation from -25 decibels or unachievable which is minimum \& worse value, to 0 decibel, which is maximum \& best value.
• Color vision — Through study completion, an average of 1 year
  Assessed with Desaturated Lanthony 15-Hue Test: an objective technic evaluating sensitivity to color \& colour vision deficiency. Test result is categorized as Abnormal for minimum \& worse evaluation; and Normal for maximum \& best evaluation.
• National Eye Institute 25-Item Visual Function Questionnaire — Through study completion, an average of 1 year
  Using a scale from 0 for minimum \& worse, to 100 for maximum \& best result; this questionnaire measures influence of visual impairment on various dimensions of quality of life such as emotional well-being and social functioning

Trial sites (1)

More Assistance Publique - Hôpitaux de Paris trials in France