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Clinical Trials in France / NCT05129150
Recruiting Observational

Cognitive Disorders and Brain Pulse

NCT05129150 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Tours
Phase
Observational
Started
2022-03-31
Last updated
2026-05-06

Condition(s) studied

Neurocognitive Disorders

Investigational drug(s) / intervention(s)

Ultrasound examination

Ultrasound examination: Ultrasound examination with Tissue Pulsatility Imaging (TPI) TPI is a relatively simple, rapid and non-invasive ultrasound examination which consists of applying a standard ultrasound probe to the acoustic window of the temporal bone to first measure the velocity of the middle cerebral artery in Doppler mode and secondly the cerebral pulsatility (CP) of a region of approximately 10cm2 centred on the middle cerebral artery in B-Echo mode. After collecting the information, the TPI examination will be performed by MRRC staff specially trained in TPI by engineers. The duration of the examination is between 20 and 30 minutes, including hardware installation. Four 30-second PC acquisitions will be collected per examination, with the patient lying supine on the bed in the day hospital room, then one measurement every minute for 3 minutes after standing.

Study summary

Following an initial consultation with a memory, resources and research centre (MRRC) doctor, a day hospital may be prescribed to carry out an assessment of cognitive disorders. Patients are then usually followed up in consultation at least once a year, in the framework of a new day hospital and/or consultations with a MRRC doctor.

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Patient benefiting from a day hospital at the MRRC of the CHU of Tours for assessment of cognitive functions Exclusion Criteria: * Refusal of TPI ultrasound examination * Patients who opposed to data processing * Patients under judicial protection

Primary outcome measure(s)

  • maximum amplitude of brain movements — one a year from inclusion visit to 5 years
    Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).
  • mean of brain movements — one a year from inclusion visit to 5 years
    Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).
  • standard deviation of brain movements — one a year from inclusion visit to 5 years
    Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).
  • powers in frequency analysis — one a year from inclusion visit to 5 years
    Measurement by ultrasound between patients with Minor Neurocognitive Disorders (mNCD) and Major Neurocognitive Disorders (MNCD).

Trial sites (1)

FacilityCityRegionStatus
University hospital Tours France Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05129150 on ClinicalTrials.gov ↗ ← All trials in France