A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma
Condition(s) studied
Investigational drug(s) / intervention(s)
Teclistamab: Participants will receive teclistamab.
Daratumumab: Participants will receive daratumumab.
Pomalidomide: Participants will receive pomalidomide.
Lenalidomide: Participants will receive lenalidomide.
Bortezomib: Participants will receive bortezomib.
Nirogacestat: Participants will receive nirogacestat.
Study summary
The purpose of this study is to characterize the safety and tolerability of teclistamab when administered in different combination regimen and to identify the optimal dose(s) of teclistamab combination regimens.
Eligibility
Primary outcome measure(s)
- Number of Participants with Incidence of Adverse Events (AEs) — Up to 2 year and 5 months
An AE can be any unfavorable and unintended sign (including an abnormal finding), symptom, or disease temporally associated with the use of a medicinal (investigational or non-investigational) product, whether or not related to that medicinal (investigational or non-investigational) product. - Number of Participants with AEs by Severity — Up to 2 year and 5 months
Number of participants with AEs by severity will be reported. - Number of Participants with Abnormalities in Laboratory Values — Up to 2 year and 5 months
Number of participants with abnormalities in laboratory values (such as serum chemistry, hematology) will be reported. - Number of Participants with Dose-Limiting Toxicity (DLT) — Up to Cycle 2 Day 21 (each cycle is of 28 days for Treatment Regimen A and 21 days for Treatment Regimen B)
The Dose Limiting Toxicities (DLTs) are based on drug related adverse events and defined as any of the following events: hematological / non hematological toxicity of Grade 3 or higher.
Trial sites (27)
| Facility | City | Region | Status |
|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | |
| University of California San Francisco | San Francisco | California | |
| Colorado Blood Cancer Institute | Denver | Colorado | |
| Winship Cancer Institute Emory University | Atlanta | Georgia | |
| Indiana University Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | |
| Washington University School Of Medicine | St Louis | Missouri | |
| Hackensack University Medical Center | Hackensack | New Jersey | |
| Memorial Sloan-Kettering Cancer Center | New York | New York | |
| Weill Cornell Medical College | New York | New York | |
| Levine Cancer Institute | Charlotte | North Carolina | |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | |
| Tennessee Oncology | Nashville | Tennessee | |
| Fred Hutchinson Cancer Center | Seattle | Washington | |
| Medical College Of Wisconsin | Milwaukee | Wisconsin | |
| St Vincents Hospital Melbourne | Fitzroy | Australia | |
| Alfred Health | Melbourne | Australia | |
| Calvary Mater Newcastle Hospital | Waratah | Australia | |
| UZA | Edegem | Belgium | |
| UZ Gent | Ghent | Belgium | |
| Centre Leon Berard | Lyon | France | |
| CHU Nantes | Nantes | France | |
| CHU de Bordeaux - Hospital Haut-Leveque | Pessac | France | |
| Chu Rennes Hopital Pontchaillou | Rennes | France | |
| Institut Universitaire du cancer de Toulouse-Oncopole | Toulouse | France | |
| University College Hospital | London | United Kingdom | |
| The Christie Nhs Foundation Trust | Manchester | United Kingdom | |
| The Royal Marsden NHS Trust Sutton | Surrey | United Kingdom |
More Janssen Research & Development, LLC trials in France
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT04722146 on ClinicalTrials.gov ↗ ← All trials in France