Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation

Condition(s) studied

Investigational drug(s) / intervention(s)

Clinical examination centered on congestion: Clinical examination centered on congestion (ASCEND, NYHA and Ambrosy Score) will be performed before discharge from hospital

Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography: Cardio-pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography will be performed before discharge from hospital

Biological: Blood sample retrieved for biological assessment and biobanking: Blood sample collection will be performed before discharge from hospital

Telephone interview: Telephone interview will be performed at 3, 12 months and 24 months after discharge from hospital

Kansas City Cardiomyopathy Questionnaire (KCCQ): Questionnaire centered on patient's quality of life at discharge and 3, 12 and 24 months after discharge

Study summary

The AHF-CODE reduced study is a prospective, non-randomized, monocenter study performed in patients with heart failure with reduced ejection fraction admitted for worsening heart failure.

The main objective of the AHF-CODE study is to identify congestion markers (clinical, biological and ultrasound) at the end of hospitalization for acute heart failure that are associated with the risk of all cause death or rehospitalization for acute heart failure within 3 months of hospital discharge.

Eligibility

Primary outcome measure(s)

• Rate of all-cause death — 3 months after hospital discharge
  composite endpoint: rate of all-cause death, hospitalization for acute heart failure or day-hospital IV diuretics injection for acute HF during 3 months following day hospitalization (with outcome 2 and 3)
• Rate of re-hospitalisation for acute heart failure — 3 months after hospital discharge
  composite endpoint: rate of all-cause death, hospitalization for acute heart failure or day-hospital IV diuretics injection for acute HF during 3 months following day hospitalization (with outcome 1 and 3)
• Rate of day-hospital or in-home IV diuretics injection for acute HF — 3 months after hospital discharge
  composite endpoint: rate of all-cause death, hospitalization for acute heart failure or day-hospital IV diuretics injection for acute HF during 3 months following day hospitalization (with outcome 1 and 2)

Trial sites (1)

More Central Hospital, Nancy, France trials in France

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