Pathogenic Study of Adult Immune Enteropathies
Condition(s) studied
Investigational drug(s) / intervention(s)
Blood sample collection; gastrointestinal biopsy: Targeted Next generation sequencing and whole exome sequencing Phenotyping of intestinal lymphocytes, single cell analyses, cytokines dosage...
Study summary
The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.
Eligibility
Primary outcome measure(s)
- Intestinal Lymphocytes count — Baseline
Lymphocytes isolation - DNA sequencing — Baseline
Targeted Next Generation sequencing
Trial sites (4)
| Facility | City | Region | Status |
|---|---|---|---|
| Hôpital Henri Mondor | Créteil | France | Not Yet Recruiting |
| Hôpital Bicêtre | Le Kremlin-Bicêtre | France | Not Yet Recruiting |
| Hôpital Saint Louis | Paris | France | Not Yet Recruiting |
| Hôpital Cochin | Paris | France | Recruiting |
More Institut National de la Santé Et de la Recherche Médicale, France trials in France
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT04280510 on ClinicalTrials.gov ↗ ← All trials in France