Neural Correlates of Movement Disorders Associated With PRRT2 Related Paroxysmal Kinesigenic Dyskinesia - an Ancillary Study of AMEDYST Research
Condition(s) studied
Investigational drug(s) / intervention(s)
Voluntary and involuntary conditions: An task fMRI/EEG acquisition during the prodromal phase preceding the episode of abnormal movements. A task fMRI/EEG acquisition the episode of abnormal movements A task fMRI/EEG acquisition when the subject voluntary mimics the sequence of events (prdrosomal phase + episode of dyskinesia)
Study summary
The main objective of this study is to investigate in real-time the neuronal correlates of paroxysmal dyskinesia episodes related to the PRRT2 mutation within this subgroup of patients (who can control paroxysmal dyskinesia episodes), and more specifically, the pathological role of the reciprocal influence between the striatum and the cerebellum in paroxysmal dyskinesia episodes.
Eligibility
Primary outcome measure(s)
- BOLD signal amplitude — Visit 1 to 5
- EEG signal amplitude — Visit 6 to 10
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Institut du Cerveau de la Moelle Epinière ICM, Hôpital Pitié Salpêtrière, | Paris | France | Recruiting |
More Institut National de la Santé Et de la Recherche Médicale, France trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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