Molecular Characterization for Understanding Biliary Atresia

Condition(s) studied

Investigational drug(s) / intervention(s)

blood sampling: collection of blood sample for preparation of DNA

skin biopsy sampling: preparation of primary cultures of dermal fibroblasts from skin biopsy sample

explanted liver of BA patients sampling: cryoconservation of liver tissue for molecular analyses

Study summary

Although considered a rare disease, Biliary Atresia (BA) is the leading cause of neonatal cholestasis and liver transplantation in children. Little is known about the molecular mechanisms that drive BA. The purpose of this study is to collect the fluid samples, explanted liver tissue samples and dermal biopsy samples to enable investigators to perform the genetic and molecular analyses that might point to the gene(s) and cellular pathway involved in etiology of BA disease.

Eligibility

Primary outcome measure(s)

• To identify the molecular mechanisms implicated in the etiology of BA — 10 Years
  To identify gene(s) and cellular pathways affected in cells and liver tissue of BA patients: sequencing experiments

Trial sites (2)

More Institut National de la Santé Et de la Recherche Médicale, France trials in France

Other trials for the same condition