Brain Injury and Cognitive Function

Condition(s) studied

Investigational drug(s) / intervention(s)

imaging: Brain activation is demonstrated by measuring signal changes in brain regions. Activations will be determined by comparison between conditions and in relation to periods of rest

Evoked Potentials: EEG signals, referenced to the right mastoid, were digitised at 125 Hz with an elliptical low-pass input filter at 49 Hz

MEG: MEG signals reflect changes in magnetic field evoked by changes in neuronal activity

Behavioural tests: Behavioural tests will be evaluated.

Study summary

The objective of this exploratory study is to elucidate the underlying cerebral mechanisms of cognitive deficits. To achieve this, the investigator will apply functional brain imaging techniques to patients suffering from cognitive deficits due to cerebral lesions.

The investigator will employ a "single-case" approach, suitable for studying rare behavioral profiles such as acquired reading disorders (alexia) or visual perception impairments (agnosia). If necessary, the investigator will use multiple non-invasive imaging methods in the same patients, including:

1. Magnetic Resonance Imaging (structural and functional), renowned for its spatial resolution and the diverse information it provides, and
2. Electrophysiological methods (MEG and EEG), notable for their temporal resolution.

The employed stimuli will consist of visual or auditory presentations of verbal material (words, sentences, numbers, etc.), potentially combined with the collection of simple vocal or motor responses (button presses).

The results will be interpreted by integrating the neuropsychological analysis of the deficit and the lesion topography.

Importantly, following the methodology of single-case neuropsychology, the stimulation protocols will be modulated and adapted to each individual case. Consequently, parallel data should be collected from healthy control subjects whenever necessary.

For protocol development, the investigator will also collect purely behavioral data, without brain imaging, from groups of control subjects.

Eligibility

Primary outcome measure(s)

• MRI (Functional Magnetic Resonance Imaging) — 13 years
  Brain activation is revealed by measuring signal changes in brain regions. Activations will be determined by comparing conditions and compared to resting periods using analysis techniques.
• MEG (Magnetoencephalography) — 13 years
  MEG signals reflect changes in the magnetic field evoked by neuronal activity. They are collected and analyzed using specific analysis methods.
• ERPs (Event-Related Potentials) — 13 years
  EEG signals, referenced to the right mastoid, are digitized at 125 Hz with a low-pass elliptical input filter at 49 Hz.

Trial sites (1)

More Institut National de la Santé Et de la Recherche Médicale, France trials in France