IMRT and Primary Transoral Surgery in the Treatment of Squamous Cell Carcinomas

Condition(s) studied

Investigational drug(s) / intervention(s)

transoral resection: The technique of transoral surgery will be left to the choice of the surgeon according to the equipment and the experience of the team and will be gathered. The options are: transoral surgery robot-assisted, endoscopic laser transoral surgery, transoral laser surgery classical instruments. The exact description of the resected area will be collected. of the cross-sections will be made for extemporaneous analysis if necessary in lateral margins and deep until complete excision.

IMRT: Intensity modulation radiotherapy (RCMI or IMRT) will be performed using techniques static or rotational (arctherapy, tomotherapy). Restraint is recommended with thermoformed mask

Study summary

Compare patients' feelings in terms of swallowing ability assessed by the overall score of MD Anderson Dysphagia Inventory (MDADI) 2 years after starting treatment between patients who have been treated with IMRT and those who were treated by transoral surgery for a squamous cell carcinoma of the early stage oropharynx.

Eligibility

Primary outcome measure(s)

• MD Anderson Dysphagia Inventory (MDADI) global score — 2 years after inclusion
  Score goes from 20 to 100. A higher score means a better ability to swallow

Trial sites (16)

More Gustave Roussy, Cancer Campus, Grand Paris trials in France

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